{"created":"2023-08-02T03:55:47.027097+00:00","id":4730,"links":{},"metadata":{"_buckets":{"deposit":"0a7db2b6-5ff1-4251-a734-ffc35b58d7ca"},"_deposit":{"created_by":10,"id":"4730","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4730"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004730","sets":["1:9","2:12","23:34:988:991"]},"author_link":["4750","4929"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"145","bibliographicPageStart":"135","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Synaptosomal associated protein of 23 kDa (SNAP23), a plasma membrane-localized soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE), is a ubiquitously expressed protein that is generally involved in fusion of the plasma membrane and secretory or endosomal recycling vesicles during several types of exocytosis. SNAP23 is expressed in phagocytes, such as neutrophils, macrophages, and dendritic cells, and functions in both exocytosis and phagocytosis. This review focuses on the function of SNAP23 in immunoglobulin G Fc receptor-mediated phagocytosis by macrophages. SNAP23 and its partner SNAREs mediate fusion of the plasma membrane with intracellular organelles or vesicles to form phagosomes as well as the fusion of phagosomes with endosomes or lysosomes to induce phagosome maturation, characterized by reactive oxygen species production and acidification. During these processes, SNAP23 function is regulated by phosphorylation. In addition, microtubule-associated protein 1A/1B light chain 3 (LC3)-associated phagocytosis, which tightly promotes or suppresses phagosome maturation depending on the foreign target, requires SNAP23 function. SNAP23 that is enriched on the phagosome membrane during LC3-associated phagocytosis may be phosphorylated or dephosphorylated, thereby enhancing or inhibiting subsequent phagosome maturation, respectively. These findings have increased our understanding of the SNAP23-associated membrane trafficking mechanism in phagocytes, which has important implications for microbial pathogenesis and innate and adaptive immune responses.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2020.08.001","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Hatsuzawa Kiyotaka, Sakurai Chiye. Regulatory Mechanism of SNAP23 in Phagosome Formation and Maturation. Yonago Acta Medica. 2020, 63(3). 135-145. doi: 10.33160/yam.2020.08.001."}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.001/_article/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.001/_article/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"1346-8049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Biology, School of Life Sciences, Faculty of Medicine, Tottori University"}]},"item_10001_text_34":{"attribute_name":"雑誌内区分","attribute_value_mlt":[{"subitem_text_value":"Review Articles: Special Contribution"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"初沢, 清隆"},{"creatorName":"ハツザワ, キヨタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hatsuzawa, Kiyotaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4750","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20256655","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20256655"},{"nameIdentifier":"100001086","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001086_ja.html"}]},{"creatorNames":[{"creatorName":"櫻井, 千恵"},{"creatorName":"サクライ, チエ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakurai, Chiye","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4929","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10589724","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10589724"},{"nameIdentifier":"100001302","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001302_ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam63(3)_135.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam63(3)_135.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4730/files/yam63(3)_135.pdf"},"version_id":"0e481f9d-43ee-418e-8ebc-998a6e6999c7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MAP1LC3A","subitem_subject_scheme":"Other"},{"subitem_subject":"membrane fusion","subitem_subject_scheme":"Other"},{"subitem_subject":"phagocytosis","subitem_subject_scheme":"Other"},{"subitem_subject":"SNAP23 protein","subitem_subject_scheme":"Other"},{"subitem_subject":"SNARE proteins","subitem_subject_scheme":"Other"},{"subitem_subject":"MAP1LC3A","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"membrane fusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phagocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SNAP23 protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SNARE proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulatory Mechanism of SNAP23 in Phagosome Formation and Maturation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulatory Mechanism of SNAP23 in Phagosome Formation and Maturation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","991"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"4730","relation_version_is_last":true,"title":["Regulatory Mechanism of SNAP23 in Phagosome Formation and Maturation"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:52:32.994556+00:00"}