{"created":"2023-08-02T03:55:47.069282+00:00","id":4731,"links":{},"metadata":{"_buckets":{"deposit":"4832a8da-c9e4-458f-99ec-90fb167648ec"},"_deposit":{"created_by":10,"id":"4731","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4731"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004731","sets":["1:9","2:12","23:34:988:991"]},"author_link":["4730"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"153","bibliographicPageStart":"146","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although there are many reports on the regulation of ion channel expression in transcription and translation, few drugs have been studied to influence post-translational modification of ion channel proteins. The Kv1.5 channel is a potassium ion channel expressed in atrial muscle, belongs to the voltage-gated K+ channel superfamily, and forms an ultrarapid delayed rectifier potassium ion current. It is important to understand the fate of these channel proteins, as cardiac Kv1.5 mutations can cause arrhythmias. Disruption of quantitative and qualitative control mechanisms of channels leads to stagnation and degradation of intracellular channel proteins. As a result, ion channel proteins are not transported to the cell membrane and are involved in the development of atrial fibrillation. This review takes the Kv1.5 channel as an example and focuses on the degradation mechanism of ion channel proteins, and discusses its application to the treatment of arrhythmia by drugs that control the mechanism of ion channel protein degradation.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2020.08.002","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Miake Junichiro. A Novel Treatment for Arrhythmias via the Control of the Degradation of Ion Channel Proteins. Yonago Acta Medica. 2020, 63(3). 146-153. doi: 10.33160/yam.2020.08.002."}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.002/_article/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.002/_article/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"1346-8049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Faculty of Medicine, Tottori University"}]},"item_10001_text_34":{"attribute_name":"雑誌内区分","attribute_value_mlt":[{"subitem_text_value":"Review Articles: Special Contribution"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三明, 淳一朗"},{"creatorName":"ミアケ, ジュンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Miake, Junichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4730","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40372677","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40372677"},{"nameIdentifier":"100000259","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000259_ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam63(3)_146.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam63(3)_146.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4731/files/yam63(3)_146.pdf"},"version_id":"70347152-5c5a-4bbb-b043-2985c4d2e903"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"arrhythmia","subitem_subject_scheme":"Other"},{"subitem_subject":"chaperon","subitem_subject_scheme":"Other"},{"subitem_subject":"degradation","subitem_subject_scheme":"Other"},{"subitem_subject":"ion channel","subitem_subject_scheme":"Other"},{"subitem_subject":"trafficking","subitem_subject_scheme":"Other"},{"subitem_subject":"arrhythmia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chaperon","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"degradation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ion channel","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trafficking","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Novel Treatment for Arrhythmias via the Control of the Degradation of Ion Channel Proteins","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Novel Treatment for Arrhythmias via the Control of the Degradation of Ion Channel Proteins","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","991"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"4731","relation_version_is_last":true,"title":["A Novel Treatment for Arrhythmias via the Control of the Degradation of Ion Channel Proteins"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:52:34.611614+00:00"}