{"created":"2023-08-02T03:55:47.300436+00:00","id":4736,"links":{},"metadata":{"_buckets":{"deposit":"df8ccf3e-86c2-4ffd-a0b1-2b0f46b73b4e"},"_deposit":{"created_by":10,"id":"4736","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4736"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004736","sets":["1:9","2:12","23:34:988:991"]},"author_link":["16903","3446","16904","16905","2396","2893","16906","349","4288","1082","16907","16908","16909","16910"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"197","bibliographicPageStart":"188","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Background] Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease related to metabolic syndrome, which can progress to liver cirrhosis. Standard medication has not been established. Pemafibrate is a selective peroxisome proliferatoractivated receptor (PPAR) α modulator. We retrospectively evaluated the efficacy of pemafibrate in patients with NAFLD. [Methods] We retrospectively enrolled 17 patients (ten men, seven women; median age, 63 years; range, 27?81 years). They were all proven to have fatty liver through imaging and had little or no history of drinking (ethanol consumption of < 20 g/day for women and < 30 g/day for men). They were administered pemafibrate from October 2018 to June 2020. [Results] After administration, serum triglyceride (TG) tended to be decreased (300.5 ± 22.5 to 239.5 ± 34.3 mg/dL, P = 0.06). Serum high-density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol levels did not change. ALT was significantly decreased (-47.4%) for six months (57.5 ± 8.8 to 30.3 ± 5.8 U/L, P < 0.01). The values of serum GGT significantly decreased (-48.7%) for sixth months (63.9 ± 10.3 to 32.8 ± 6.6 U/L, P < 0.01). Aspartate aminotransferase (AST) to platelet ratio (APRI), a fibrosis marker, also was significantly decreased in the sixth month (0.7 ± 0.1 to 0.4 ± 0.1, P < 0.05). Body mass index (BMI) and hemoglobin A1c (HbA1c) showed no significant change. [Conclusion] Pemafibrate dramatically ameliorated the values of liver function tests and APRI in patients with NAFLD.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2020.08.009","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Ikeda Suguru, Sugihara Takaaki, Hoshino Yoshiki,et al. Pemafibrate Dramatically Ameliorated the Values of Liver Function Tests and Fibrosis Marker in Patients with Non-Alcoholic Fatty Liver Disease. Yonago Acta Medica. 2020, 63(3). 188-197. doi: 10.33160/"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.009/_article/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/yam/63/3/63_2020.08.009/_article/","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam63-3/63-3contents.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"1346-8049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Gastroenterology and Nephrology, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Cardiovascular Medicine and Endocrinology and Metabolism, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Cardiovascular Medicine and Endocrinology and Metabolism, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Cardiovascular Medicine and Endocrinology and Metabolism, School of Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Department of Cardiovascular Medicine  and Endocrinology and Metabolism, School of Medicine, Faculty of Medicine, Tottori University"}]},"item_10001_text_34":{"attribute_name":"雑誌内区分","attribute_value_mlt":[{"subitem_text_value":"Original Article"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"イケダ, スグル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16903","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"スギハラ, タカアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugihara, Takaaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3446","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60753853","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60753853"},{"nameIdentifier":"100001245","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001245_ja.html"}]},{"creatorNames":[{"creatorName":"ホシノ, ヨウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16904","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"マツキ, ユカコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16905","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ナガハラ, タカカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagahara, Takakazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2396","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100001934","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001934_ja.html"}]},{"creatorNames":[{"creatorName":"オカノ, ジュンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Okano, Jun-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2893","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00343278","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00343278"},{"nameIdentifier":"100000340","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000340_ja.html"}]},{"creatorNames":[{"creatorName":"キタオ, ソノコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16906","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"フジオカ, ヨウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujioka, Youhei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"349","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10791048","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10791048"},{"nameIdentifier":"100001785","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001785_ja.html"}]},{"creatorNames":[{"creatorName":"ヤマモト, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4288","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90303966","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90303966"},{"nameIdentifier":"100000280","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000280_ja.html"}]},{"creatorNames":[{"creatorName":"イソモト, ハジメ","creatorNameLang":"ja-Kana"},{"creatorName":"Isomoto, Hajime","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1082","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90322304","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90322304"},{"nameIdentifier":"100001541","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001541_ja.html"}]},{"creatorNames":[{"creatorName":"Ikeda, Suguru","creatorNameLang":"en"},{"creatorName":"イケダ, スグル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16907","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hoshino, Yoshiki","creatorNameLang":"en"},{"creatorName":"ホシノ, ヨウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16908","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuki, Yukako","creatorNameLang":"en"},{"creatorName":"マツキ, ユカコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16909","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitao, Sonoko","creatorNameLang":"en"},{"creatorName":"キタオ, ソノコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16910","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam63(3)_188.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam63(3)_188.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4736/files/yam63(3)_188.pdf"},"version_id":"fb374bfe-f941-41fd-8ce5-19fa16ba07e6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"non-alcoholic fatty liver disease","subitem_subject_scheme":"Other"},{"subitem_subject":"nonalcoholic steatohepatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"pemafibrate","subitem_subject_scheme":"Other"},{"subitem_subject":"liver function","subitem_subject_scheme":"Other"},{"subitem_subject":"liver fibrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"non-alcoholic fatty liver disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nonalcoholic steatohepatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pemafibrate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liver function","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liver fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pemafibrate Dramatically Ameliorated the Values of Liver Function Tests and Fibrosis Marker in Patients with Non-Alcoholic Fatty Liver Disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pemafibrate Dramatically Ameliorated the Values of Liver Function Tests and Fibrosis Marker in Patients with Non-Alcoholic Fatty Liver Disease","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","991"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"4736","relation_version_is_last":true,"title":["Pemafibrate Dramatically Ameliorated the Values of Liver Function Tests and Fibrosis Marker in Patients with Non-Alcoholic Fatty Liver Disease"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:52:53.654783+00:00"}