{"created":"2023-08-02T03:55:49.582861+00:00","id":4771,"links":{},"metadata":{"_buckets":{"deposit":"ba5e1315-4784-49f3-b87a-8ab7317c0a7c"},"_deposit":{"created_by":10,"id":"4771","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4771"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004771","sets":["1:9","2:12","23:34:993:994"]},"author_link":["17090","1855","2784","2075","17091","405","17092","660","1772","17093","17094","17095","17096","17097"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"76","bibliographicPageStart":"67","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Background] Adenoid cystic carcinoma (ACC) is a relatively rare malignant neoplasm that occurs in salivary glands and various other organs. Recent studies have revealed that a significant proportion of ACCs harbor gene alterations involving MYB or MYBL1 (mostly fusions with NFIB) in a mutually-exclusive manner. However, its clinical significance remains to be well-established. [Methods] We investigated clinicopathological and molecular features of 36 ACCs with special emphasis on the significance of MYBL1 alterations. Reverse-transcription polymerase-chain reaction (RT-PCR) and fluorescence in-situ hybridization (FISH) were performed to detect MYB/MYBL1-NFIB fusions and MYBL1 alterations, respectively. Immunohistochemistry was performed to evaluate MYB expression in the tumors. The results were correlated with clinicopathological profiles of the patients. [Results] RT-PCR revealed MYB-NFIB and MYBL1-NFIB fusions in 10 (27.8%) and 7 (19.4%) ACCs, respectively, in a mutually-exclusive manner. FISH for MYBL1 rearrangements was successfully performed in 11 cases, and the results were concordant with those of RT-PCR. Immunohistochemically, strong MYB expression was observed in 23 (63.9%) tumors, none of which showed MYBL1 alterations. Clinicopathologically, a trend of a better disease-specific survival was noted in patients with MYBL1 alterations than in those with MYB-NFIB fusions and/or strong MYB expression; however, the difference was not significant. Interestingly, we found tumors with MYBL1 alterations significantly frequently occurred in the mandibular regions (P = 0.012). Moreover, literature review revealed a similar tendency in a previous study. [Conclusion] Our results suggest that there are some biological or etiological differences between ACCs with MYB and MYBL1 alterations. Moreover, the frequent occurrence of MYBL1-associated ACC in the mandibular regions suggests that MYB immunohistochemistry is less useful in diagnosing ACCs arising in these regions. Further studies are warranted to verify our findings.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2019.03.010","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2019, 62(1), 67-76"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/yam/62/1/62_2019.03.010/_article/-char/en","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam62-1/62-1contents.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"1346-8049"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"},{"subitem_text_value":"Department of Pathology, Tottori University Hospital"},{"subitem_text_value":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University"},{"subitem_text_value":"Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"},{"subitem_text_value":"Department of Pathology, Tottori University Hospital"},{"subitem_text_value":"Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Department of Pathology, Tottori Prefectural Central Hospital"},{"subitem_text_value":"Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University"},{"subitem_text_value":"Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, Tottori University Hospital/Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Division of Otolaryngology, Head and Neck Surgery, Department of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, Tottori Prefectural Central Hospital"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathobiological Science and Technology, School of Health Sciences, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Endo, Yukari"},{"creatorName":"エンドウ, ユカリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuwamoto, Satoshi"},{"creatorName":"クワモト, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kuwamoto, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ohira, Takahito"},{"creatorName":"オオヒラ, タカヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Ohira, Takahito","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Matsushita, Michiko"},{"creatorName":"マツシタ, ミチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsushita, Michiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Matsushige, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuhara, Takahiro"},{"creatorName":"フクハラ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuhara, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakamoto, Shu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Kazuhiko"},{"creatorName":"ハヤシ, カズヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kugoh, Hiroyuki"},{"creatorName":"クゴウ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kugoh, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Hirooka, Yasuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Yukari","creatorNameLang":"en"},{"creatorName":"エンドウ, ユカリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsushige, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamoto, Shu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirooka, Yasuaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-22"}],"displaytype":"detail","filename":"yam62(1)_67.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam62(1)_67.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4771/files/yam62(1)_67.pdf"},"version_id":"cc2c6f55-8ceb-45e9-9b6c-8756be35b83b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adenoid cystic carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"fluorescence in-situ hybridization","subitem_subject_scheme":"Other"},{"subitem_subject":"mandibular neoplasms","subitem_subject_scheme":"Other"},{"subitem_subject":"oncogene fusion","subitem_subject_scheme":"Other"},{"subitem_subject":"prognosis","subitem_subject_scheme":"Other"},{"subitem_subject":"adenoid cystic carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fluorescence in-situ hybridization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mandibular neoplasms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oncogene fusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prognosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","994"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-06-17"},"publish_date":"2019-06-17","publish_status":"0","recid":"4771","relation_version_is_last":true,"title":["Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:54:57.167909+00:00"}