{"created":"2023-08-02T03:55:50.936621+00:00","id":4795,"links":{},"metadata":{"_buckets":{"deposit":"03880ed4-31c1-42ba-ae06-a64b7664143c"},"_deposit":{"created_by":10,"id":"4795","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4795"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004795","sets":["1:9","2:12","23:34:993:995"]},"author_link":["17254","2430","2568","685","2075","1855","1365","660"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"243","bibliographicPageStart":"240","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Graves’ disease occurs predominantly in women. Epstein-Barr virus (EBV) mainly persists in human B lymphocytes, and its reactivation stimulates antibody production. We previously suggested that the EBV reactivation-induced production of TRAb and IgM at 100 nM estradiol (pregnant level) was lower than that at 0 nM estradiol and that class switch recombination may be increased by estradiol. In this study, we examined the effect of estradiol on EBV reactivation. We identified the expression of EBV-glycoprotein 350/220 (gp350/220) in the late phase of reactivation and plasma cell differentiation of EBV-infected cells using 72A1 antibody and CD138 antibody, respectively. We found the mean ratio of gp 350/220(+) CD138(+) cells at 100 nM estradiol was higher than that at 0 nM estradiol. These results suggested that EBV-infected cells could survive with keeping the ability of antibody production in 100 nM estradiol, which is consistent with the improvement of Graves’ disease during maternity and exacerbation postpartum.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Medical Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2019.06.010","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Sayuri Hara, Keiko Nagata, Yuji Nakayama, Katsumi Higaki, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Kazuhiko Hayashi, High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam62-2/62-2contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam62-2/62-2contents.html","subitem_relation_type_select":"URI"}},{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.jstage.jst.go.jp/article/yam/62/2/62_2019.06.010/_article/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/yam/62/2/62_2019.06.010/_article/","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"1346-8049"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Radioisotope Science, Research Initiative Center, Organization for Research Initiative and Promotion"},{"subitem_text_language":"en","subitem_text_value":"Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hara, Sayuri","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nakayama, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Higaki, Katsumi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Matsushita, Michiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kuwamoto, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Kato, Masako","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Hayashi, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-15"}],"displaytype":"detail","filename":"yam62(2)_240.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam62(2)_240.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4795/files/yam62(2)_240.pdf"},"version_id":"186a9381-7e52-4864-8097-0ee18e5bf13b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anti-gp350/220 antibody (72A1)","subitem_subject_scheme":"Other"},{"subitem_subject":"Epstein-Barr virus, estradiol","subitem_subject_scheme":"Other"},{"subitem_subject":"Graves’ disease","subitem_subject_scheme":"Other"},{"subitem_subject":"reactivation","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-gp350/220 antibody (72A1)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epstein-Barr virus, estradiol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Graves’ disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"reactivation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","995"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-23"},"publish_date":"2019-07-23","publish_status":"0","recid":"4795","relation_version_is_last":true,"title":["High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves’ Disease Patients and Healthy Controls"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:56:20.080777+00:00"}