{"created":"2023-08-02T03:55:52.409658+00:00","id":4823,"links":{},"metadata":{"_buckets":{"deposit":"877c8dce-2927-41b4-b0bb-2458390e5a9c"},"_deposit":{"created_by":10,"id":"4823","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4823"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004823","sets":["1:9","2:12","23:34:998:1000"]},"author_link":["3905","3391","17364","780","3118","4168","95","2271","17365","17366","3086","1103","377","17367","17368","17369"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"136","bibliographicPageStart":"128","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【Background】Indirubin, a constituent of the Chinese herbal medicine “Qing-Dai,” has anti-cancer and anti-inflammatory activities. We aimed to evaluate the efficacy of indirubin for ameliorating colonic inflammation in a mouse model of inflammatory bowel disease. 【Methods】Mice with dextran sulfate sodium (DSS)induced acute and chronic colitis were treated with indirubin in their diet. Clinical and histologic changes were evaluated. In addition, colon levels of interleukin-6, a critical pro-inflammatory mediator, was detected by enzyme-linked immunosorbent assay. 【Results】In the model of acute colitis, indirubin treatment improved the loss of body weight. Histology of colonic tissue revealed that indirubin treatment improved the histology grading of colitis (P = 0.02), the extent of submucosal fibrosis (P = 0.018), the number of mucosal toluidine blue-positive cells (P = 0.004) and colon length (P = 0.01). In the model of chronic colitis, indirubin treatment had no significant effect on pathologic findings except for colon length (P = 0.003). However, indirubin administration significantly reduced colon levels of interleukin-6 in the chronic-colitis model (P = 0.001). 【Conclusion】Our study clearly showed that oral intake of indirubin can improve murine DSS-induced colitis (which mimics human inflammatory bowel disease).","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2018.06.005","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2018,61(2), 128-136"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam61-2/61-2contents.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"1346-8049"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine/Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Sky Clinic"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Organ Pathology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tokuyasu, Naruo"},{"creatorName":"Tokuyasu, Naruo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3905","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000393","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000393_ja.html"}]},{"creatorNames":[{"creatorName":"Shomori, 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Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"377","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40314330","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40314330"},{"nameIdentifier":"100001755","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001755_ja.html"}]},{"creatorNames":[{"creatorName":"Amano, Kuniki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17367","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchinaka, Ei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yagyu, Takuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17369","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-20"}],"displaytype":"detail","filename":"yam61(2)_128.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam61(2)_128.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4823/files/yam61(2)_128.pdf"},"version_id":"97affeba-c756-43b1-ad60-e754ad58d80d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chinese herbal medicine","subitem_subject_scheme":"Other"},{"subitem_subject":"DSS-induced colitis model","subitem_subject_scheme":"Other"},{"subitem_subject":"indirubin","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory bowel disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Qing-Dai","subitem_subject_scheme":"Other"},{"subitem_subject":"Chinese herbal medicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DSS-induced colitis model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"indirubin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory bowel disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Qing-Dai","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Indirubin, a Constituent of the Chinese Herbal Medicine Qing-Dai, Attenuates Dextran Sulfate Sodium-induced Murine Colitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Indirubin, a Constituent of the Chinese Herbal Medicine Qing-Dai, Attenuates Dextran Sulfate Sodium-induced Murine Colitis","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1000"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"4823","relation_version_is_last":true,"title":["Indirubin, a Constituent of the Chinese Herbal Medicine Qing-Dai, Attenuates Dextran Sulfate Sodium-induced Murine Colitis"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T23:57:51.893241+00:00"}