{"created":"2023-08-02T03:55:54.361254+00:00","id":4863,"links":{},"metadata":{"_buckets":{"deposit":"5ab1f4ef-05da-4470-9425-b92d87e31c3e"},"_deposit":{"created_by":10,"id":"4863","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4863"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004863","sets":["1:9","2:12","23:34:1003:1006"]},"author_link":["2075","17562","17563","1855","2430","1365","1585","660","17564","17565"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"153","bibliographicPageStart":"145","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Background] Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and-negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma(HCV), and Burkitt lymphoma (EBV). [Methods] To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs. [Results] AID expression was significantly higher in MCPyV-negative MCCs than MCPyV-positive ones (P = 0.026), although expression of NF-κB p65 (phospho S536) (AID-enhancer) was significantly higher in MCPyV-positive MCCs than MCPyV-negative ones (P = 0.034). Expressions of PAX5 and c-Myb were not significantly different between these subgroups. Expressions of AID and AID-regulating factors were not correlated to prognosis of MCC patients. [Conclusion] Our findings suggest that although pathogen-induced AID expression through upregulationof NF-κB may be relevant to carcinogenesis of MCPyV-positive MCCs, the significantly higher aberrant AID expression in MCPyV-negative MCCs is consistent with the fact that MCPyV-negative MCCs have an extremely extremely higher mutation burden than MCPyV-positive ones.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2017.09.002","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2017, 60(3), 145-153"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam60-3/yam-60-145.pdf"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam60-3/yam-60-145.pdf","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"1346-8049"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine"},{"subitem_text_value":"Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University"},{"subitem_text_value":"Department of Histopathology, The Christie NHS Foundation Trust"},{"subitem_text_value":"Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine"},{"subitem_text_value":"Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsushita, Michiko"},{"creatorName":"Matsushita, 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Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1855","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60567189","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60567189"},{"nameIdentifier":"100000360","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000360_ja.html"}]},{"creatorNames":[{"creatorName":"Nagata, Keiko"},{"creatorName":"Nagata, Keiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2430","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50304209","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50304209"},{"nameIdentifier":"100001779","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001779_ja.html"}]},{"creatorNames":[{"creatorName":"Kato, Masako"},{"creatorName":"Kato, 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Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"660","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30180962","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30180962"},{"nameIdentifier":"100000220","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000220_ja.html"}]},{"creatorNames":[{"creatorName":"Iwasaki, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nonaka, Daisuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17565","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-16"}],"displaytype":"detail","filename":"yam60(3)_145.pdf","filesize":[{"value":"3.5 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polyomavirus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1006"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"4863","relation_version_is_last":true,"title":["Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:00:11.777287+00:00"}