{"created":"2023-08-02T03:55:55.160905+00:00","id":4876,"links":{},"metadata":{"_buckets":{"deposit":"21f49502-7cf2-40fd-96b6-d9f08c7ab1eb"},"_deposit":{"created_by":10,"id":"4876","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4876"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004876","sets":["1:9","2:12","23:34:1003:1007"]},"author_link":["572","17636","292","4720","17637","3792","17638","17639"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"223","bibliographicPageStart":"227","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Yonago Acta Medica"},{"bibliographic_title":"Yonago Acta Medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Background]SR-16234 is a selective estrogen receptor modulator (SERM) structurally different from approved SERM and has been reported to have estrogen receptor (ER) α antagonistic activity and strong affinity with a weak partial agonistic activity to ERβ receptor. SR-16234 showed strong inhibitory effects on transplanted endometrial cysts in the endometriosis model of rat and mouse. In this clinical trial, efficacy and safety of SR-16234 have been evaluated in endometriosis patients. [Methods]This trial was an open-label single arm clinical trial. Ten patients with dysmenorrhea and pelvic pain associated with endometriosis and adenomyosis were enrolled in this trial, and received 40 mg of SR-16234 once daily for 12 weeks. The primary endpoint was the visual analogue scale (VAS) of pelvic pain. The secondary endpoints included dysmenorrhea score, pelvic pain score, objective observations (stiffness of Douglas’ pouch, limitation of uterine movement, size of ovarian chocolate cysts, thickness of endometrium, and serum CA125 concentration) and safety. [Results]After oral administration of SR-16234 40 mg for 12 weeks, there were statistically significant decreases in pelvic pain VAS, total pelvic pain score, total dysmenorrhea score, stiffness of Douglas’ pouch, limitation of uterine movement compared with the baseline values. [Conclusion]The present trial suggested that a selective estrogen receptor modulator could be used for treatment of pain associated with endometriosis for the first time.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.33160/yam.2017.12.003","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta Medica. 2017, 60(4), 227-223"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam60-4/60-4contents.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam60-4/60-4contents.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05135710","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"1346-8049"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Obstetrics and Gynecology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Department of Obstetrics and Gynecology, Kurashiki Heisei Hospital"},{"subitem_text_value":"Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital"},{"subitem_text_value":"Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital"},{"subitem_text_value":"Department of Data Science, The Institute of Statistical Mathematics"},{"subitem_text_value":"Department of Obstetrics and Gynecology, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Kurashiki Heisei Hospital"},{"subitem_text_language":"en","subitem_text_value":"Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Advanced Medicine, Innovation and Clinical Research Center, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Data Science, The Institute of Statistical Mathematics"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Harada, Tasuku"},{"creatorName":"Harada, Tasuku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"572","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40218649","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40218649"},{"nameIdentifier":"100000223","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000223_ja.html"}]},{"creatorNames":[{"creatorName":"Ohta, Ikuko"}],"nameIdentifiers":[{"nameIdentifier":"17636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Yusuke"},{"creatorName":"Endo, Yusuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"292","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100001268","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001268_ja.html"}]},{"creatorNames":[{"creatorName":"Sunada, Hiroshi"},{"creatorName":"Sunada, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4720","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100001617","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001617_ja.html"}]},{"creatorNames":[{"creatorName":"Noma, Hisashi"}],"nameIdentifiers":[{"nameIdentifier":"17637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taniguchi, Fuminori"},{"creatorName":"Taniguchi, Fuminori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3792","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40322218","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40322218"},{"nameIdentifier":"100000380","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000380_ja.html"}]},{"creatorNames":[{"creatorName":"Ohta, Ikuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noma, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17639","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-29"}],"displaytype":"detail","filename":"yam60(4)_227.pdf","filesize":[{"value":"702.1 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yam60(4)_227.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4876/files/yam60(4)_227.pdf"},"version_id":"8819d650-40ec-4521-a98f-540ff824a8ce"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"estrogen receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"endometriosis","subitem_subject_scheme":"Other"},{"subitem_subject":"selective estrogen receptor modulator","subitem_subject_scheme":"Other"},{"subitem_subject":"pelvic pain","subitem_subject_scheme":"Other"},{"subitem_subject":"open clinical trial","subitem_subject_scheme":"Other"},{"subitem_subject":"estrogen receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endometriosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"selective estrogen receptor modulator","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pelvic pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"open clinical trial","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SR-16234, a Novel Selective Estrogen Receptor Modulator for Pain Symptoms with Endometriosis: An Open-label Clinical Trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SR-16234, a Novel Selective Estrogen Receptor Modulator for Pain Symptoms with Endometriosis: An Open-label Clinical Trial","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1007"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"4876","relation_version_is_last":true,"title":["SR-16234, a Novel Selective Estrogen Receptor Modulator for Pain Symptoms with Endometriosis: An Open-label Clinical Trial"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:00:53.921873+00:00"}