{"created":"2023-08-02T03:56:01.160224+00:00","id":4997,"links":{},"metadata":{"_buckets":{"deposit":"6a3a8536-2bc7-420a-981d-70b609628e41"},"_deposit":{"created_by":10,"id":"4997","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"4997"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00004997","sets":["1:9","2:12","23:34:1033:1034"]},"author_link":["18290","597","18291","1993","18292","2174","4183","18293","18294","18295"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"11","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the mechanism underlying the protective effects of ginger against gastric damage induced by aspirin in rats. Gastric mucosal lesions were produced by orally administering 200 mg/kg aspirin suspended in 1% carboxymethylcellulose solution to pyloric-ligated male Wistar rats. Ginger powder (200 mg/kg) markedly reduced the aspirin-induced gastric hemorrhagic ulcer area. The total acidity of gastric juice was not significantly influenced by aspirin or ginger. Ginger powder did not affect the aspirin-induced reduction in mucosal prostaglandin E2 (PGE2) content; however, it did ameliorate the aspirin-induced increases in mucosal activity of the inducible form of NO synthase (iNOS) and plasma tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels. In the next experiment, high and low doses of 6-gingerol and 6-shogaol were used instead of ginger powder in the same experimental model to examine their roles in the anti-ulcer mechanism of ginger. Both 6-gingerol and 6-shogaol reduced aspirin induced ulcer formation, mucosal iNOS and plasma TNF-α and IL-1β levels. In conclusion, ginger powder prevents the aspirin induced gastric ulcer formation by reducing mucosal iNOS activity and the plasma levels of inflammatory cytokines but does not affect gastric juice or acid production or mucosal PGE2 content. This protective effect of ginger powder against gastric ulcers may be attributable to both gingerol and shogaol.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2011, 54(1), 11-19"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam54-1/yam54_011-019.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.lib.tottori-u.ac.jp/yam/yam/yam54-1/yam54_011-019.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wang, Zhongzhi"}],"nameIdentifiers":[{"nameIdentifier":"18290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Junichi"},{"creatorName":"Hasegawa, Junichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"597","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60189529","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60189529"}]},{"creatorNames":[{"creatorName":"Wang, Xinhui"}],"nameIdentifiers":[{"nameIdentifier":"18291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuda, Akiko"},{"creatorName":"Matsuda, Akiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1993","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00346347","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00346347"}]},{"creatorNames":[{"creatorName":"Tokuda, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"18292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miura, Norimasa"},{"creatorName":"Miura, Norimasa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2174","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30325005","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30325005"}]},{"creatorNames":[{"creatorName":"Watanabe, Tatsuo"},{"creatorName":"Watanabe, Tatsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4183","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60182929","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60182929"},{"nameIdentifier":"100000290","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000290_ja.html"}]},{"creatorNames":[{"creatorName":"Wang, Zhongzhi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Xinhui","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokuda, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18295","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2011-03-11"}],"displaytype":"detail","filename":"54_011-019.pdf","filesize":[{"value":"580.7 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"54_011-019.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/4997/files/54_011-019.pdf"},"version_id":"da84328b-226d-47a2-94b6-979b34793329"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aspirin","subitem_subject_scheme":"Other"},{"subitem_subject":"gastric damage","subitem_subject_scheme":"Other"},{"subitem_subject":"ginger powder","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"inducible form of NO synthase activity","subitem_subject_scheme":"Other"},{"subitem_subject":"aspirin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gastric damage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ginger powder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammatory cytokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inducible form of NO synthase activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1034"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"4997","relation_version_is_last":true,"title":["Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-28T04:24:07.009766+00:00"}