{"created":"2023-08-02T03:56:01.647717+00:00","id":5008,"links":{},"metadata":{"_buckets":{"deposit":"43565913-da64-4659-b2d3-8184c34a8520"},"_deposit":{"created_by":10,"id":"5008","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5008"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005008","sets":["1:9","2:12","23:34:1038:1039"]},"author_link":["4296","3086","18348","18349","905","18350","18351"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"16","bibliographicPageStart":"9","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Some studies suggest that small populations of CD4+ T cells with activation-independent, constitutive, NKG2D expression are found in normal peripheral blood and have immune suppressive properties. The present study was designed to investigate NKG2D expression on CD4+ T lymphocytes and its relationship to immune evasion in colorectal cancer patients. We examined NKG2D expression on both circulating and tumor infiltrating CD4+ and CD8+ T cells or NK cells and evaluated it by multicolor flow cytometry. Furthermore, intracellular cytokine staining was carried out to determine the cytokine profile of NKG2D+CD4+ T cells in colorectal cancer patients. As a result, NKG2D expression on circulating and tumor-infiltrating CD8+ T cells and NK cells was downregulated in colorectal cancer patients. On the other hand, circulating and tumor-infiltrating NKG2D+CD4+ T cells increased in colorectal cancer patients. NKG2D+CD4+ T cells produced more immune suppressive cytokines, such as interleukin-10 and transforming growth factor-1β, than did NKG2D-CD4+ T cells. Increased NKG2D+CD4+ T cells as well as decreased NKG2D expression on CD8+ T cells and NK cells may be one of the key mechanisms responsible for immune evasion by tumors in colorectal cancer.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2010, 53(1), 9-16"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Manabu"},{"creatorName":"Yamamoto, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4296","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100001149","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001149_ja.html"}]},{"creatorNames":[{"creatorName":"Saito, Hiroaki"},{"creatorName":"Saito, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3086","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20335532","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20335532"},{"nameIdentifier":"100000156","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000156_ja.html"}]},{"creatorNames":[{"creatorName":"Kihara, Kyoichi"}],"nameIdentifiers":[{"nameIdentifier":"18348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katano, Kuniyuki"}],"nameIdentifiers":[{"nameIdentifier":"18349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikeguchi, Masahide"},{"creatorName":"Ikeguchi, Masahide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"905","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20193188","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20193188"}]},{"creatorNames":[{"creatorName":"Kihara, Kyoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katano, Kuniyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18351","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2010-03-15"}],"displaytype":"detail","filename":"53_009-016.pdf","filesize":[{"value":"303.5 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"53_009-016.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5008/files/53_009-016.pdf"},"version_id":"e7d918cd-52b1-43c4-a9cf-abc91b8d9a36"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD4+ T lymphocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"NKG2D","subitem_subject_scheme":"Other"},{"subitem_subject":"CD4+ T lymphocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NKG2D","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"NKG2D+CD4+ T Cells with Immune Suppressive Property Increase in Patients with Colorectal Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NKG2D+CD4+ T Cells with Immune Suppressive Property Increase in Patients with Colorectal Cancer","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1039"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5008","relation_version_is_last":true,"title":["NKG2D+CD4+ T Cells with Immune Suppressive Property Increase in Patients with Colorectal Cancer"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:48:57.439530+00:00"}