{"created":"2023-08-02T03:56:01.775651+00:00","id":5011,"links":{},"metadata":{"_buckets":{"deposit":"bde68ba6-58e0-4baa-9798-bfb0ac248c90"},"_deposit":{"created_by":10,"id":"5011","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5011"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005011","sets":["1:9","2:12","23:34:1038:1040"]},"author_link":["2609"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"36","bibliographicPageStart":"29","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Niemann-Pick C1-Like 1 (NPC1-L1), as its name indicates, was identified in 2000 as a homolog of NPC1. Its major physiological function was clarified by a research group in Shöring’s laboratory who had long been searching for a target of ezetimibe, a cholesterol-lowering drug. They published a paper on 2004 in Science, reporting a reduction of intestinal cholesterol absorption and a lack of effects of ezetimibe in NPC1-L1 knockout mice. With subsequent studies that confirmed their findings, it is now clear that NPC1-L1 is a key player in one of the major pathways of intestinal cholesterol absorption and that it is the target of ezetimibe. This review summarizes what has been shown up to now about the structure and function of NPC1-L1. This review also refers to ABCG5/G8, a member of ABC family transporters, which co-localizes with NPC1-L1 on the intestinal epithelial cells and appears to work in a closely related manner.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2010, 53(2), 29-36"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam53-2/yam53_029-036.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.lib.tottori-u.ac.jp/yam/yam/yam53-2/yam53_029-036.html","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Biological Regulations, School of Health Science, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ninomiya, Haruaki"},{"creatorName":"Ninomiya, Haruaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2609","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80212124","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80212124"},{"nameIdentifier":"100000212","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000212_ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2010-07-16"}],"displaytype":"detail","filename":"53_029-036.pdf","filesize":[{"value":"315.5 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"53_029-036.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5011/files/53_029-036.pdf"},"version_id":"72bba861-44b5-40e2-bb27-a1f0bb543f21"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ABCG5/G8","subitem_subject_scheme":"Other"},{"subitem_subject":"cholesterol","subitem_subject_scheme":"Other"},{"subitem_subject":"low-density lipoprotein","subitem_subject_scheme":"Other"},{"subitem_subject":"Niemann-Pick","subitem_subject_scheme":"Other"},{"subitem_subject":"Niemann-Pick disease type C1-like 1","subitem_subject_scheme":"Other"},{"subitem_subject":"ABCG5/G8","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cholesterol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"low-density lipoprotein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Niemann-Pick","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Niemann-Pick disease type C1-like 1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1040"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5011","relation_version_is_last":true,"title":["Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:49:09.320809+00:00"}