{"created":"2023-08-02T03:56:02.405369+00:00","id":5023,"links":{},"metadata":{"_buckets":{"deposit":"da0282d8-db10-4ed5-b508-d0c73a515951"},"_deposit":{"created_by":10,"id":"5023","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5023"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005023","sets":["1:9","2:12","23:34:1043:1044"]},"author_link":["2077","18432","18433","18434","423","18435","18436","18437"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"46","bibliographicPageStart":"37","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Previous studies have shown that excretory/secretory (ES) products from plerocercoids of Spirometra erinaceieuropaei have immunosuppressive activities. We report here that a 130 kDa glycoprotein (ES130) purified from ES products as a suppressive factor of nitric oxide synthesis in LPS-stimulated RAW 264.7 cells inhibited the gene expression of 3 chemokines, regulated on activation normal T cell expressed and secreted (CCL5/RANTES), macrophage inflammatory protein 2 (CXCL2/MIP-2), interferon-inducible protein 10 kDa (CXCL10/IP-10) in RAW 264.7 cells and mouse peritoneal macrophages stimulated with LPS for 3 h. These chemokines are important factors for recruitment of inflammatory leukocytes. RANTES acts on monocytes, basophils, lymphocytes, natural killer cells and eosinophils. MIP-2 is a potent chemoattactant for neutrophils, while IP-10 binds to Th1 cells. Nearly 80% of MIP-2 gene expression and 50% of IP-10 gene ex-pression in peritoneal macrophages stimulated with LPS for 8 h was suppressed as well as these chemokine production by the preincubation with 100 ng/mL of ES130 or 5000 ng/mL crude ES products for 24 h. On the other hand the mRNA expression of RANTES in macrophages stimulated with LPS for 8 h or 24 h was not inhibited by ES130 or crude ES products, while the RANTES chemokine levels in the incubation medium were significantly suppressed. These results suggest that ES130 may attenuate inflammation around the plerocercoids by inhibiting these chemokine production.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2009, 52(1), 37-46"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Medical Zoology, Department of Microbiology and Immunology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Medical Zoology, Department of Microbiology and Immunology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Medical Zoology, Department of Microbiology and Immunology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Technical Support Section, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Medical Zoology, Department of Microbiology and Immunology, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"*"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuura, Haruyo"},{"creatorName":"Matsuura, Haruyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2077","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70243409","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70243409"}]},{"creatorNames":[{"creatorName":"Tomioku, Asumi"}],"nameIdentifiers":[{"nameIdentifier":"18432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, Satoko"}],"nameIdentifiers":[{"nameIdentifier":"18433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tademoto, Sayuri"}],"nameIdentifiers":[{"nameIdentifier":"18434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumoto, Soji"},{"creatorName":"Fukumoto, Soji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"423","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60111126","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60111126"},{"nameIdentifier":"100000234","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000234_ja.html"}]},{"creatorNames":[{"creatorName":"Tomioku, Asumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18435","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, Satoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18436","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tademoto, Sayuri","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18437","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-04-09"}],"displaytype":"detail","filename":"52_037-046.pdf","filesize":[{"value":"286.2 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"52_037-046.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5023/files/52_037-046.pdf"},"version_id":"1827749a-9e0b-451e-abe2-0d773ec949ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"chemokine","subitem_subject_scheme":"Other"},{"subitem_subject":"excretory/secretory products","subitem_subject_scheme":"Other"},{"subitem_subject":"lipopolysaccharide","subitem_subject_scheme":"Other"},{"subitem_subject":"Spirometra erinaceieuropaei","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chemokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"excretory/secretory products","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lipopolysaccharide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spirometra erinaceieuropaei","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Suppression of Chemokine Gene Expression and Production in LPS-Stimulated Macrophages by a 130 kDa Glycoprotein from Plerocercoids of Spirometra erinaceieuropaei","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Suppression of Chemokine Gene Expression and Production in LPS-Stimulated Macrophages by a 130 kDa Glycoprotein from Plerocercoids of Spirometra erinaceieuropaei","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1044"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5023","relation_version_is_last":true,"title":["Suppression of Chemokine Gene Expression and Production in LPS-Stimulated Macrophages by a 130 kDa Glycoprotein from Plerocercoids of Spirometra erinaceieuropaei"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:49:48.503823+00:00"}