{"created":"2023-08-02T03:56:02.536893+00:00","id":5025,"links":{},"metadata":{"_buckets":{"deposit":"048b5895-888a-4db1-a817-2754ae980048"},"_deposit":{"created_by":10,"id":"5025","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5025"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005025","sets":["1:9","2:12","23:34:1043:1044"]},"author_link":["18440","3096","2573","18441","2804","18442","18443"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"72","bibliographicPageStart":"57","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Colorectal carcinogenesis involves environmental factors and genetic predispositions. Recent studies have suggested the associations between colorectal neoplasm and functional polymorphism of matrix metalloproteinases (MMPs) and cytokine genes. In this study, we analyzed polymorphisms of MMPs and tumor necrosis factor (TNF)-alpha genes, focusing on the susceptibility to colorectal neoplasm and the tumor progression. The subjects were 186 patients (95 men and 91 women) who underwent total colonoscopy, and were classified into cancer, adenoma and non-neoplasm (control) groups of 47, 72 and 67 patients, respectively. The polymorphisms at the MMP-2 ?1306C/T, MMP-3 ?1171 5A/6A, MMP-7 ?181A/G, MMP-9 ?1562C/T and TNF-alpha ?308G/A loci were analyzed. Regarding background factors, significant differences were found in the age, sex ratio and alcohol-drinking and cigarette-smoking histories in the adenoma and cancer groups, compared to those in the control group. On these factors-adjusted logistic regression analysis of polymorphisms and disease susceptibility, no significant difference was noted in the frequency of any polymorphism in the adenoma and cancer groups, compared to those in the control group. The analysis of the involvement of polymorphisms in tumor progression in the adenoma and cancer groups revealed that the odds ratio for the MMP-3 5A allele was significantly higher in the cancer group (2.74; 95% confidence interval = 1.11?6.74, P = 0.02). The polymorphisms of MMP genes and TNF-alpha genes were not associated with the susceptibility to colorectal neoplasm, but the involvement of the MMP-3 5A allele in the progression of adenoma to cancer was suggested.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2009, 52(1), 57-72"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Child Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine"},{"subitem_text_value":"Department of Child Neurology, National Center Hospital of Neurology and Psychiatry"},{"subitem_text_value":"Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University"},{"subitem_text_value":"International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women’s Medical University"},{"subitem_text_value":"Division of Child Neurology, Institute of Neurological Sciences, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakurai, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Yoshiaki"},{"creatorName":"Saito, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nanba, Eiji"},{"creatorName":"Nanba, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohno, Kousaku"},{"creatorName":"Ohno, Kousaku","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sakurai, Yuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Toshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-04-09"}],"displaytype":"detail","filename":"52_057-072.pdf","filesize":[{"value":"384.9 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"52_057-072.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5025/files/52_057-072.pdf"},"version_id":"ae138bd2-98b1-4d5e-8c36-a8fdd59fd0ee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"colorectal neoplasm","subitem_subject_scheme":"Other"},{"subitem_subject":"gene analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"matrix metalloproteinase","subitem_subject_scheme":"Other"},{"subitem_subject":"polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor-alpha","subitem_subject_scheme":"Other"},{"subitem_subject":"colorectal neoplasm","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gene analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"matrix metalloproteinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor-alpha","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Variations in Clinical Findings of Patients with Identical Tuberous Sclerosis Gene Mutations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Variations in Clinical Findings of Patients with Identical Tuberous Sclerosis Gene Mutations","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1044"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5025","relation_version_is_last":true,"title":["Variations in Clinical Findings of Patients with Identical Tuberous Sclerosis Gene Mutations"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:49:57.000545+00:00"}