@article{oai:repository.lib.tottori-u.ac.jp:00005028,
 author = {Kataoka, Hideyuki and Kataoka, Hideyuki and Nakano, Seiji and Kunimoto, Yasuomi and Kunimoto, Yasuomi and Sugie, Naoko and Osaki, Mitsuhiko and Osaki, Mitsuhiko and Uzawa, Narikazu and Yoshida, Mitsuaki A. and Oshimura, Mitsuo and Oshimura, Mitsuo and Kitano, Hiroya and Nakano, Seiji and Sugie, Naoko and Uzawa, Narikazu and Yoshida, Mitsuaki A. and Kitano, Hiroya},
 issue = {2},
 journal = {Yonago Acta medica, Yonago Acta medica},
 month = {Jun},
 note = {Genomic imprinting is an epigenetic feature that plays a significant role in carcinogenesis. In this study, we examined the expression status of an imprinted gene, paternally expressed gene 1/mesoderm-specific transcript PEG1/MEST, in 38 cases of head and neck squamous cell carcinomas (HNSCCs) and in 17 oral squamous cancer cell lines. Loss of imprinting (LOI) of PEG1/MEST was found in 8 of 10 (80%) in tumor specimens, and 6 of 10 (60%) informative cases even in the extracted normal tissue specimens. As for the oral squamous cancer cell lines, LOI was detected in 5 of 8 (62.5%) informative cases in PEG1/MEST. Thus, these data showed that abnormal expression of PEG1/MEST was found at a high frequency in the tumor, the extracted normal tissue specimens and the oral squamous cancer cell lines. PEG1/MEST LOI in extracted normal tissue specimens may have a potential individual cancer risk for HNSCC.},
 pages = {85--90},
 title = {Allele-Specific Expression Analysis of PEG1/MEST in Head and Neck Squamous Cell Carcinomas},
 volume = {52},
 year = {2009}
}