{"created":"2023-08-02T03:56:03.008109+00:00","id":5033,"links":{},"metadata":{"_buckets":{"deposit":"cadc0e65-2386-493c-aaff-3344b6fc1a1f"},"_deposit":{"created_by":10,"id":"5033","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5033"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005033","sets":["1:9","2:12","23:34:1043:1047"]},"author_link":["18482","18483","18484","18485","765","18486","18487","18488","18489"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"125","bibliographicPageStart":"121","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Denaturing high-performance liquid chromatography (DHPLC), which has recently been developed as an automated method to detect mutations, is at least ten times less expensive than the direct sequencing method; however, its sensitivity and specificity for cardiac myosin-binding protein C (MYBPC3) gene mutations in hypertrophic cardiomyopathy have not been reported yet. A mutation analysis of exons 1 to 35 of MYBPC3 gene from 20 Japanese patients with hypertrophic cardiomyopathy was performed using DHPLC and direct sequencing. Compared to direct sequencing, the sensitivity and specificity of DHPLC were 87.5% and 97.42%, respectively. Its positive and negative predictive values were 41.18% and 99.74%. The positive and negative likelihood ratios were 33.95 and 0.13, and the prevalence was 2.02%. DHPLC showed high sensitivity and specificity for detecting MYBPC3 gene mutations in hypertrophic cardiomyopathy. The use of this complementary sequencing method should reduce the cost of detection of MYBPC3 gene mutations, and could be used to screen patients with hypertrophic cardiomyopathy.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2009, 52(4), 121-125"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Bio-function, Tottori University Graduate School of Medical Science"},{"subitem_text_value":"Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Bio-function, Tottori University Graduate School of Medical Science"},{"subitem_text_value":"Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University"},{"subitem_text_value":"Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Bio-function, Tottori University Graduate School of Medical Science"},{"subitem_text_value":"Division of Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Bio-function, Tottori University Graduate School of Medical Science"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bahrudin, Udin"}],"nameIdentifiers":[{"nameIdentifier":"18482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizuta, Einosuke"}],"nameIdentifiers":[{"nameIdentifier":"18483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dewi, Ariani Mahayu"}],"nameIdentifiers":[{"nameIdentifier":"18484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nindita, Yora"}],"nameIdentifiers":[{"nameIdentifier":"18485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisatome, Ichiro"},{"creatorName":"Hisatome, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"765","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60211504","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60211504"},{"nameIdentifier":"100000307","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000307_ja.html"}]},{"creatorNames":[{"creatorName":"Bahrudin, Udin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizuta, Einosuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dewi, Ariani Mahayu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nindita, Yora","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18489","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2010-01-14"}],"displaytype":"detail","filename":"52_121-125(1).pdf","filesize":[{"value":"88.0 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"52_121-125(1).pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5033/files/52_121-125(1).pdf"},"version_id":"9bbcc5ef-a8ec-4cbc-ac21-f5e54a32fca5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cardiac myosin-binding protein C gene","subitem_subject_scheme":"Other"},{"subitem_subject":"denaturing high-performance liquid chroma-tography","subitem_subject_scheme":"Other"},{"subitem_subject":"hypertrophic cardiomyopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"mutation detection","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiac myosin-binding protein C gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"denaturing high-performance liquid chroma-tography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypertrophic cardiomyopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mutation detection","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sensitivity and Specificity of Denaturing HPLC to Detect MYBPC3 Gene Mutations in Hypertrophic Cardiomyopathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sensitivity and Specificity of Denaturing HPLC to Detect MYBPC3 Gene Mutations in Hypertrophic Cardiomyopathy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1047"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5033","relation_version_is_last":true,"title":["Sensitivity and Specificity of Denaturing HPLC to Detect MYBPC3 Gene Mutations in Hypertrophic Cardiomyopathy"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:50:23.721224+00:00"}