{"created":"2023-08-02T03:56:05.040900+00:00","id":5064,"links":{},"metadata":{"_buckets":{"deposit":"65f47a7e-6e7f-483f-99f9-8c5279b55b6d"},"_deposit":{"created_by":10,"id":"5064","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5064"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005064","sets":["1:9","2:12","23:34:1058:1059"]},"author_link":["18688","18689","18690","18691","752","905","18692","18693","18694","18695"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"17","bibliographicPageStart":"9","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The phosphatidylinositol-3 kinase (PI3K)-Akt signaling pathway is known to protect a variety of cells from apoptosis. Phospho-Akt (p-Akt) can facilitate cell survival and inactivating pro-apoptotic proteins. The phosphatase and tensin homologue deleted on chromosome ten (PTEN) is a natural biological inhibitor of p-Akt in the PI3K-Akt pathway. The relationship between the expressions of p-Akt and PTEN and pancreatic cancer is unknown. Here, we designed a study to clarify the prognostic significance of p-Akt and PTEN expression in patients with pancreatic cancer. Immunohistochemical analysis of p-Akt and PTEN protein was performed on 51 specimens of pancreatic cancer. The expression of p-Akt was detected in 32 patients (62.7%). The expression of p-Akt was frequently detected in patients with advanced stage pancreatic cancer (P = 0.0233). Patients with p-Akt-positive tumors had significantly worse prognoses than those with p-Akt-negative tumors (overall survival; 11.3% versus 25.7%). The expression of PTEN was detected in 26 patients (51.0%). Patients with PTEN-positive tumors had significantly better prognoses than those with PTEN-negative tumors (overall survival; 29.9% versus 0%). Patients with p-Akt-positive and PTEN-negative tumors had significantly worse prognoses than those with p-Akt-negative and PTEN-positive tumors (overall survival; 0% versus 39.1%). Multivariate analysis revealed that expression of p-Akt was an independent prognostic factor as well as arterial invasion and lymph node metastasis. The expression of p-Akt and PTEN proteins determined by immunohistochemistry may be a new method for predicting the prognosis of patients with pancreatic cancer.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2006, 49(1), 9-17"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ozaki-Ohgami, Yoshimi"}],"nameIdentifiers":[{"nameIdentifier":"18688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwamoto, Akemi"}],"nameIdentifiers":[{"nameIdentifier":"18689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshioka, Shizue"}],"nameIdentifiers":[{"nameIdentifier":"18690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatebe, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"18691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirooka, Yasuaki"},{"creatorName":"Hirooka, Yasuaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"752","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40243399","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40243399"},{"nameIdentifier":"100000228","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000228_ja.html"}]},{"creatorNames":[{"creatorName":"Ikeguchi, Masahide"},{"creatorName":"Ikeguchi, Masahide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"905","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20193188","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20193188"}]},{"creatorNames":[{"creatorName":"Ozaki-Ohgami, Yoshimi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwamoto, Akemi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshioka, Shizue","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatebe, Shigeru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18695","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-09"}],"displaytype":"detail","filename":"49_009-017.pdf","filesize":[{"value":"489.7 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"49_009-017.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5064/files/49_009-017.pdf"},"version_id":"6efd0ead-c0cb-40b0-9af4-b7fd21ca69f6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatic cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphatase and tensin homologue deleted on chromosome ten","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphorylated-Akt","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatic cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphatase and tensin homologue deleted on chromosome ten","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphorylated-Akt","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of phospho-Akt and PTEN Proteins Predicts the Survival of Patients with Pancreatic Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of phospho-Akt and PTEN Proteins Predicts the Survival of Patients with Pancreatic Cancer","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1059"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5064","relation_version_is_last":true,"title":["Expression of phospho-Akt and PTEN Proteins Predicts the Survival of Patients with Pancreatic Cancer"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:52:08.459054+00:00"}