{"created":"2023-08-02T03:56:05.173790+00:00","id":5066,"links":{},"metadata":{"_buckets":{"deposit":"212b90f3-1b06-4f4f-b8bb-c7a451159179"},"_deposit":{"created_by":10,"id":"5066","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5066"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005066","sets":["1:9","2:12","23:34:1058:1059"]},"author_link":["18702","18703","4050","2346","18704","2381","18705","18706","18707"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"37","bibliographicPageStart":"29","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The profibrogenic role of endothelin-1 (ET-1) and angiotensin-II (AT-II) in renal fibrosis remains disputed. We therefore studied the effect of ET-1 and AT-II on rat mesangial cells (CRL-2573), the major source of extracellular matrix proteins in the kidney. ET-1 stimulated DNA synthesis assessed by BrdU uptake in microtiter tetrazolium assay in a dose dependent manner, but AT-II did not. Proliferation of the mesangial cells by ET-1 was suppressed by 15% with BQ123, an endothelin receptor A antagonist, which suggested a significant role of the endothelin receptor A on growth stimulation. In the mesangial cells, ET-1 increased the mRNA expressions of procollagen α1 (I), transforming growth factor-β1, connective tissue growth factor, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-13 in dose dependent manners, whereas AT-II had exerted no effect on the expression of these mRNAs. These data suggested that ET-1 might be involved in renal fibrosis through the mesangial cell proliferation and/or the increase in fibrogenic cytokines.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2006, 49(1), 29-37"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"18702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koda, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"18703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueki, Masaru"},{"creatorName":"Ueki, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4050","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60542256","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60542256"},{"nameIdentifier":"100000324","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000324_ja.html"}]},{"creatorNames":[{"creatorName":"Munemura, Chishio"},{"creatorName":"Munemura, Chishio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2346","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000438","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000438_ja.html"}]},{"creatorNames":[{"creatorName":"Maeta, Satoko"}],"nameIdentifiers":[{"nameIdentifier":"18704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murawaki, Yoshikazu"},{"creatorName":"Murawaki, Yoshikazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2381","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90144659","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90144659"}]},{"creatorNames":[{"creatorName":"Yamamoto, Satoru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koda, Masahiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeta, Satoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18707","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-09"}],"displaytype":"detail","filename":"49_029-037.pdf","filesize":[{"value":"340.1 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"49_029-037.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5066/files/49_029-037.pdf"},"version_id":"18b90ded-7e3b-49e8-8ceb-79e84b4749be"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"angiotensin-II","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin-1","subitem_subject_scheme":"Other"},{"subitem_subject":"extracellular matrix metabolism","subitem_subject_scheme":"Other"},{"subitem_subject":"mesangial cell","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensin-II","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"extracellular matrix metabolism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mesangial cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1059"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5066","relation_version_is_last":true,"title":["Effects of Endothelin-1 and Angiotensin-II on Extracellular Matrix Metabolism in a Rat Mesangial Cell Line, CRL-2573"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:52:15.409621+00:00"}