{"created":"2023-08-02T03:56:05.887969+00:00","id":5079,"links":{},"metadata":{"_buckets":{"deposit":"42341d06-a278-47ac-bbde-57af8d40d451"},"_deposit":{"created_by":10,"id":"5079","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5079"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005079","sets":["1:9","2:12","23:34:1063:1064"]},"author_link":["18776","938","18777","18778","18779","18780","18781"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"40","bibliographicPageStart":"33","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The pharmacokinetic characteristic of ketamine, particularly the shift from the epidural space to the cerebrospinal fluid (CSF), is still unclear. Furthermore pharmacokinetic differences between racemic ketamine and S(+)-ketamine are not clearly described when administered into the epidural space. We measured plasma and CSF concentrations of racemic ketamine and S(+)-ketamine after 2 mg/kg intravenous or 2 mg/kg epidural injection in 32 rabbits, and calculated pharmacokinetic parameters by the moment analysis method. The elimination half time of S(+)-ketamine was significantly shorter than that of racemic ketamine and the systemic distribution volume of S(+)-ketamine was significantly smaller than that of racemic ketamine in the CSF. Pharmacokinetic parameters in the CSF after epidural injection of racemic versus S(+)-ketamines were: maximum concentration, 0.4 ± 0.1 versus 0.6 ± 0.2 ?g/mL (not significant); time to maximum concentration, 9.7 ± 2.1 versus 9.0 ± 3.4 min (not significant); elimination half time, 127.1 ± 25.2 versus 89.3 ± 19.4 min (P = 0.005); area under the curve, 56.4 ± 6.4 versus 56.6 ± 11.0 ?g?mL/min (not significant); and distribution volume, 19,463.5 ± 3266.1 versus 13,613.3 ± 4895.2 mL (P = 0.014), respectively. When injected intravenously, there was no significant difference in these parameters of the CSF between racemic and S(+)-ketamines. Racemic ketamine passed easily through the blood brain barrier when administered intravenously. It also shifted to the CSF through the systemic circulation, even when they were administered epidurally. S(+)-Ketamine had similar movement as racemic ketamine.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2005, 48(1), 33-40"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Anesthesiology and Critical Care Medicine, Department of Surgery, Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Adachi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"18776","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inagaki, Yoshimi"},{"creatorName":"Inagaki, Yoshimi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"938","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40184717","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40184717"},{"nameIdentifier":"100000092","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000092_ja.html"}]},{"creatorNames":[{"creatorName":"Okazaki, Naoto"}],"nameIdentifiers":[{"nameIdentifier":"18777","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishibe, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"18778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Adachi, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okazaki, Naoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishibe, Yuichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18781","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-09"}],"displaytype":"detail","filename":"48_033-040.pdf","filesize":[{"value":"199.0 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"48_033-040.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5079/files/48_033-040.pdf"},"version_id":"7a11c799-f87a-475c-8a64-e6a7fc4c89f5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"analgesia","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebrospinal fluid","subitem_subject_scheme":"Other"},{"subitem_subject":"epidural administratin;ketamine","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"analgesia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebrospinal fluid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"epidural administratin;ketamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1064"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5079","relation_version_is_last":true,"title":["Racemic Ketamine and S(+)-Ketamine Concentrations in Cerebrospinal Fluid after Epidural and Intravenous Administration in Rabbits"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:52:58.708776+00:00"}