{"created":"2023-08-02T03:56:06.431488+00:00","id":5088,"links":{},"metadata":{"_buckets":{"deposit":"8b7f692d-93f6-4da2-bbb0-0884b5f2c693"},"_deposit":{"created_by":10,"id":"5088","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5088"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005088","sets":["1:9","2:12","23:34:1068:1069"]},"author_link":["18834","423","18835","715","18836","18837"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"15","bibliographicPageStart":"7","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have reported that excretory/secretory (ES) products from Spirometra erinaceieuropaei plerocercoids suppress production and gene expression of tumor necrosis factor (TNF)-α in murine macrophages stimulated with lipopolysaccharide. The present study demonstrates that ES products suppress TNF-α, interleukin (IL)-1β and intercellular adhesion molecule (ICAM)-1 gene expression in human monocytic leukemia cell line THP-1 stimulated with Plasmodium falciparum-cultured medium (Pf-CM). Inhibition of extracellular-signal regulated protein kinase 1/2 (ERK1/2) with PD98059 reduced TNF-α, IL-1β and ICAM-1 gene expression; on the contrary inhibition of p38 mitogen-activated protein kinase (MAPK) with SB203580 increased the expression of these genes. These findings indicated that ERK1/2, but not p38 MAPK pathway is important for induction of TNF-α, IL-1β and ICAM-1 gene expression in Pf-CM stimulated THP-1 monocytes. ES products additionally suppress IL-1β, but not TNF-α and ICAM-1 gene expression in Pf-CM stimulated THP-1 cells treated with PD98059. We hypothesize that ES products may be useful in reducing falciparum malaria-induced inflammatory response and sequestration in the late stage of malarial diseases such as cerebral malaria.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2004, 47(1), 7-15"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Molecular Medical Zoology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Dirgahayu, Paramasari"}],"nameIdentifiers":[{"nameIdentifier":"18834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumoto, Soji"},{"creatorName":"Fukumoto, Soji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"423","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60111126","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60111126"},{"nameIdentifier":"100000234","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000234_ja.html"}]},{"creatorNames":[{"creatorName":"Tademoto, Sayuri"}],"nameIdentifiers":[{"nameIdentifier":"18835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirai, Kazumitsu"},{"creatorName":"Hirai, Kazumitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20093940","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20093940"}]},{"creatorNames":[{"creatorName":"Dirgahayu, Paramasari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tademoto, Sayuri","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18837","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-09"}],"displaytype":"detail","filename":"47_007-015.pdf","filesize":[{"value":"79.2 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"47_007-015.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5088/files/47_007-015.pdf"},"version_id":"ecd7a8ae-b914-4806-9205-a14c886d3d90"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"human monocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"mitogen-activated protein kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasmodium falciparum","subitem_subject_scheme":"Other"},{"subitem_subject":"Spirometra erinaceieuropaei","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor-α","subitem_subject_scheme":"Other"},{"subitem_subject":"human monocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mitogen-activated protein kinase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasmodium falciparum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spirometra erinaceieuropaei","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor-α","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Regulation of TNF-α, IL-1β and ICAM-1 Gene Expression in THP-1 Monocytes Stimulated with Plasmodium falciparum-Cultured Medium by Excretory/Secretory Products from Spirometra erinaceieuropaei Plerocercoids","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Regulation of TNF-α, IL-1β and ICAM-1 Gene Expression in THP-1 Monocytes Stimulated with Plasmodium falciparum-Cultured Medium by Excretory/Secretory Products from Spirometra erinaceieuropaei Plerocercoids","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1069"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5088","relation_version_is_last":true,"title":["Regulation of TNF-α, IL-1β and ICAM-1 Gene Expression in THP-1 Monocytes Stimulated with Plasmodium falciparum-Cultured Medium by Excretory/Secretory Products from Spirometra erinaceieuropaei Plerocercoids"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:53:31.698611+00:00"}