@article{oai:repository.lib.tottori-u.ac.jp:00005105,
 author = {Watanabe, Tatsuo and Watanabe, Tatsuo and Miyoshi, Michio and Miyoshi, Michio and Nagata, Katsumi and Nagata, Katsumi and Imoto, Toshiaki and Imoto, Toshiaki},
 issue = {2},
 journal = {Yonago Acta medica, Yonago Acta medica},
 month = {Jun},
 note = {Angiotensin II (ANG II) has been shown to have proinflammatory properties. To investigate whether ANG II is involved in the lipopolysaccharide (LPS)-induced production of a pyrogenic/proinflammatory cytokine, interleukin-6 (IL-6), we examined the effects of an angiotensin-converting-enzyme (ACE) inhibitor, lisinopril, on LPS-induced fever and on the expression of IL-6 mRNA in the spleen of dehydrated rats (in which the secretion of ANG II increases). The results showed that the ACE inhibitor significantly inhibited LPS-induced fever as well as the splenic expression of IL-6 mRNA in dehydrated rats. It is suggested that endogenous ANG II may be involved in the production of IL-6 that occurs in response to LPS, and thereby contribute to the LPS-induced febrile response in dehydrated rats.},
 pages = {49--55},
 title = {Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats},
 volume = {46},
 year = {2003}
}