{"created":"2023-08-02T03:56:07.525393+00:00","id":5105,"links":{},"metadata":{"_buckets":{"deposit":"f5178b2f-5425-4d34-8dca-b4582ca4563b"},"_deposit":{"created_by":10,"id":"5105","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5105"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005105","sets":["1:9","2:12","23:34:1073:1075"]},"author_link":["4183","2222","2429","934"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"55","bibliographicPageStart":"49","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Angiotensin II (ANG II) has been shown to have proinflammatory properties. To investigate whether ANG II is involved in the lipopolysaccharide (LPS)-induced production of a pyrogenic/proinflammatory cytokine, interleukin-6 (IL-6), we examined the effects of an angiotensin-converting-enzyme (ACE) inhibitor, lisinopril, on LPS-induced fever and on the expression of IL-6 mRNA in the spleen of dehydrated rats (in which the secretion of ANG II increases). The results showed that the ACE inhibitor significantly inhibited LPS-induced fever as well as the splenic expression of IL-6 mRNA in dehydrated rats. It is suggested that endogenous ANG II may be involved in the production of IL-6 that occurs in response to LPS, and thereby contribute to the LPS-induced febrile response in dehydrated rats.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2003, 46(2), 49-55"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine"},{"subitem_text_value":"Division of Integrative Physiology, Department of Functional, Morphological and Regulatory Science, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Tatsuo"},{"creatorName":"Watanabe, Tatsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4183","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60182929","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60182929"},{"nameIdentifier":"100000290","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000290_ja.html"}]},{"creatorNames":[{"creatorName":"Miyoshi, Michio"},{"creatorName":"Miyoshi, Michio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2222","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20093627","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20093627"}]},{"creatorNames":[{"creatorName":"Nagata, Katsumi"},{"creatorName":"Nagata, Katsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2429","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30208011","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30208011"},{"nameIdentifier":"100000194","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000194_ja.html"}]},{"creatorNames":[{"creatorName":"Imoto, Toshiaki"},{"creatorName":"Imoto, Toshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"934","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10109639","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10109639"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-08"}],"displaytype":"detail","filename":"46_049-055.pdf","filesize":[{"value":"54.3 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"46_049-055.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5105/files/46_049-055.pdf"},"version_id":"df11f836-0046-45cb-a179-ffb5f3aad62a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"angiotensin-converting-enzyme inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-6","subitem_subject_scheme":"Other"},{"subitem_subject":"lipopolysaccharide","subitem_subject_scheme":"Other"},{"subitem_subject":"spleen","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensin-converting-enzyme inhibitor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lipopolysaccharide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spleen","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1075"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5105","relation_version_is_last":true,"title":["Angiotensin-Converting-Enzyme Inhibitor, Lisinopril, Reduces Lipopolysaccharide-Induced Expression of Splenic Interleukin-6 mRNA in Dehydrated Rats"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:54:25.132478+00:00"}