{"created":"2023-08-02T03:56:08.746443+00:00","id":5127,"links":{},"metadata":{"_buckets":{"deposit":"8416f487-760a-4653-9fff-97a11fe90303"},"_deposit":{"created_by":10,"id":"5127","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5127"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005127","sets":["1:9","2:12","23:34:1078:1082"]},"author_link":["19020","19021"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"102","bibliographicPageStart":"95","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Effects of estradiol (E2) on the urinary bladder of old female rats were investigated by morphological, immunohistochemical and apoptosis-related gene analysis. Sixteen-month-old female Wistar rats were divided into the following 5 groups: normal controls; rats replaced with low-dose E2 for 2 and 4 weeks, respectively; and rats replaced with high-dose E2 for 2 and 4 weeks, respectively. After treatment, the bladders were removed, weighed and stained with hematoxylin and eosin, and immunostained by monoclonal antibodies against Bcl-2 and Bax proteins. Further, the expression of apoptosis-related genes bcl-2 and bax were investigated by PCR analysis, and evaluated by computerized quantification. Immunostained bladders showed no difference between control and E2-replaced rats in reactivity against Bcl-2 protein. In contrast, against Bax protein, control rats showed immunoreactivity, whereas E2-replaced rats showed little reactivity. Upon mRNA analysis, the expression of bax mRNA was suppressed in the E2-replaced rats as compared with the controls, though the expression of bcl-2 mRNA showed no difference among groups. These results suggest that E2 administration affects the expression of apoptosis-related genes and suppressees apoptotic action, and that these changes could consequently alter voiding behavior.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2002, 45(3), 95-102"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892883","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Urology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohata, Ryo"}],"nameIdentifiers":[{"nameIdentifier":"19020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohata, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19021","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-08"}],"displaytype":"detail","filename":"45_095-102.pdf","filesize":[{"value":"61.7 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"45_095-102.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5127/files/45_095-102.pdf"},"version_id":"5a52256c-7eb5-48c7-858c-744e734d4e53"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"bladder","subitem_subject_scheme":"Other"},{"subitem_subject":"estrogen","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bladder","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"estrogen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Estrogen Replacement Therapy on the Expression of Apoptosis-Related Genes in Old Female Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Estrogen Replacement Therapy on the Expression of Apoptosis-Related Genes in Old Female Rats","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1082"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5127","relation_version_is_last":true,"title":["Effects of Estrogen Replacement Therapy on the Expression of Apoptosis-Related Genes in Old Female Rats"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:55:43.015268+00:00"}