{"created":"2023-08-02T03:56:09.076495+00:00","id":5132,"links":{},"metadata":{"_buckets":{"deposit":"433132d2-1b90-48f3-b7ef-c899586233da"},"_deposit":{"created_by":10,"id":"5132","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5132"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005132","sets":["1:9","2:12","23:34:1083:1084"]},"author_link":["19042","1220","977","19043"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"16","bibliographicPageStart":"7","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To determine whether protoporphyric liver injury affects hepatic dendritic cells (DC) and Kupffer cells, we examined liver tissues of griseofulvin-induced protoporphyric mice using histological and immunohistochemical methods. After 1 week of griseofulvin feeding, the protoporphyric liver showed prominent hepatomegaly and a gradual increase in histopathological changes such as hepatocellular hypertrophy, focal necrosis and brown pigment deposits. After 4 weeks of treatment, marked ductular reaction was observed in the liver tissue. Immunohistochemical analyses indicated that the density of NLDC-145-positive hepatic DC gradually decreased during griseofulvin feeding. However, the index of the number of DC in the whole liver appeared to fall sharply after 6 weeks. In contrast, the density of F4/80-positive Kupffer cells gradually increased during griseofulvin feeding. In the spleen and lung, no significant differences were noted in the distribution of NLDC-145-positive DC between experimental and control mice. These results suggested that griseofulvin-induced protoporphyria leads to a specific decrease in the density of hepatic DC due to hepatomegaly until 4 weeks of treatment and is substantial after 6 weeks. This substantial decrease of hepatic DC might have been induced by some alterations in protoporphyric liver injury including ductular reaction at a later stage in this experiment. Since hepatic DC were reduced in number, they seemed to have no significant relation to the progression of griseofulvin-induced protoporphyric liver injury. However, the decrease of hepatic DC might affect the cellular immune response in protoporphyria.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2001, 44(1), 7-16"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Second Department of Anatomy, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Anatomy, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Anatomy, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kashiwagi, Ryota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaidoh, Toshiyuki"},{"creatorName":"Kaidoh, Toshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Inoue, Takao"},{"creatorName":"Inoue, Takao","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kashiwagi, Ryota","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-09"}],"displaytype":"detail","filename":"44_007-016.pdf","filesize":[{"value":"344.2 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"44_007-016.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5132/files/44_007-016.pdf"},"version_id":"2b1fda2e-7c1d-45e0-bd2b-9aa89e4bae1c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dendritic cell","subitem_subject_scheme":"Other"},{"subitem_subject":"griseofulvin","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"Kupffer cell","subitem_subject_scheme":"Other"},{"subitem_subject":"protoporphyria","subitem_subject_scheme":"Other"},{"subitem_subject":"dendritic cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"griseofulvin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kupffer cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protoporphyria","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Immunohistochemical Study of Dendritic Cells and Kupffer Cells in Griseofulvin-Induced Protoporphyric Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunohistochemical Study of Dendritic Cells and Kupffer Cells in Griseofulvin-Induced Protoporphyric Mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1084"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5132","relation_version_is_last":true,"title":["Immunohistochemical Study of Dendritic Cells and Kupffer Cells in Griseofulvin-Induced Protoporphyric Mice"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:55:57.904023+00:00"}