{"created":"2023-08-02T03:56:09.724760+00:00","id":5143,"links":{},"metadata":{"_buckets":{"deposit":"ea1a805f-2e86-499b-a0a5-1a74b472d8de"},"_deposit":{"created_by":10,"id":"5143","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5143"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005143","sets":["1:9","2:12","23:34:1083:1085"]},"author_link":["19090","19091","2573","19092","19093","19094","19095"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"114","bibliographicPageStart":"107","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The molecular pathogenesis of cholangiocarcinoma (CC) remains unclear. β-Catenin functions in both intercellular adhesion and signal transduction. As a signaling molecule, mutations in exon 3 of the β-catenin gene encoding the regions phosphorylated by glycogen synthase kinase (GSK)-3β stabilize this protein in cytoplasm. Subsequently, accumulated β-catenin protein translocates to nuclei and up-regulates the transcriptional activity of genes involved in oncogenesis. Recently, mutations in exon 3 of the β-catenin gene were detected in various carcinomas. Using polymerase chain reaction (PCR)-single-strand conformational polymorphism (SSCP) analysis, direct sequencing and subcloning-sequencing, we investigated mutations of exon 3 of the β-catenin gene in CC. Mutations were found in 26 out of 33 (78.8%) CC tumor samples. All of the mutations were heterozygous 1-base deletions at codon 15, resulting in a stop codon at codon 46. This is the first study demonstrating the presence of β-catenin gene mutations in CC. However, it was suggested that this mutation might not be involved in deregulation of β-catenin signaling, because no correlation was observed between the β-catenin mutation and immunolocalization of β-catenin protein.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2001, 44(2), 107-114"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Second Department of Pathology, Tottori University Faculty of Medicine"},{"subitem_text_value":"Second Department of Pathology, Tottori University Faculty of Medicine"},{"subitem_text_value":"Gene Research Center, Tottori University"},{"subitem_text_value":"Second Department of Pathology, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyake, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"19090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Kanenori"}],"nameIdentifiers":[{"nameIdentifier":"19091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nanba, Eiji"},{"creatorName":"Nanba, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2573","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40237631","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40237631"},{"nameIdentifier":"100000739","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000739_ja.html"}]},{"creatorNames":[{"creatorName":"Terada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"19092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyake, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Kanenori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Terada, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19095","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-08"}],"displaytype":"detail","filename":"44_107-114.pdf","filesize":[{"value":"98.6 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"44_107-114.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5143/files/44_107-114.pdf"},"version_id":"8dc008c6-e02c-4e3d-aa25-47a6634cffb5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"β-catenin","subitem_subject_scheme":"Other"},{"subitem_subject":"cholangiocarcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"deletion","subitem_subject_scheme":"Other"},{"subitem_subject":"exon 3","subitem_subject_scheme":"Other"},{"subitem_subject":"mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cholangiocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"deletion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"exon 3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mutation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Frequent Mutations in the β-Catenin Gene in Cholangiocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Frequent Mutations in the β-Catenin Gene in Cholangiocarcinoma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1085"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5143","relation_version_is_last":true,"title":["Frequent Mutations in the β-Catenin Gene in Cholangiocarcinoma"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:56:33.735520+00:00"}