{"created":"2023-08-02T03:56:10.227809+00:00","id":5153,"links":{},"metadata":{"_buckets":{"deposit":"6fe7fb83-85b8-4cc1-a431-aad1d7439c61"},"_deposit":{"created_by":10,"id":"5153","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5153"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005153","sets":["1:9","2:12","23:34:1087:1088"]},"author_link":["19128","19129","19130","2573","19131","19132","19133","19134","19135"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"38","bibliographicPageStart":"27","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined the possible involvement of vitamin D receptor (VDR) gene polymorphisms in patients on maintenance hemodialysis and further investigated the relation between VDR genotypes and bone histology. Two hundred and nine patients undergoing regular hemodialysis (male/female ratio, 124/85) were included in this study. DNA was extracted from peripheral blood leukocytes. VDR genotypes were analyzed as restriction fragment length polymorphisms, by using BsmI, ApaI, TaqI and FokI. Lumbar bone mineral density was measured by dual-energy X-ray absorptiometry, and expressed as a Z-score. Serum 1,25(OH)2D3, osteocalcin and ntact-parathyroid hormone (i-PTH) were determined by an immunoradiometric assay. In 97 patients, bone biopsy as performed and the histology was divided into osteitis fibrosa, mild lesion, dynamic bone disease and osteomalacia. Serum levels of osteocalcin, i-PTH and bone mineral density were significantly lower in the presence of B, A, t and f alleles. However, in this study, we did not find any association between bone histology and the four VDR genotypes. We concluded that renal osteodystrophy in dialysis patients was modified by environmental factors such as medication with active vitamin D, age, gender and duration of chronic renal failure, and that the impact of the VDR allelic effect may play a small role in determining on bone histology.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2000, 43(1), 27-38"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Second Department of Internal Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Internal Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Internal Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Gene Research Center, Tottori University"},{"subitem_text_value":"Division of Nephrology, Sanin Rosai Hospital"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kohama, Kiyotaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uemasu, Jiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawasaki, Hironaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nanba, Eiji"},{"creatorName":"Nanba, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Tokumoto, Akihide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kohama, Kiyotaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uemasu, Jiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawasaki, Hironaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokumoto, Akihide","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-08"}],"displaytype":"detail","filename":"43_027-038.pdf","filesize":[{"value":"186.7 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"43_027-038.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5153/files/43_027-038.pdf"},"version_id":"5d122203-e240-464c-a4c9-d056abfa43ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bone mineral density","subitem_subject_scheme":"Other"},{"subitem_subject":"hemodialysis","subitem_subject_scheme":"Other"},{"subitem_subject":"renal osteodystrophy","subitem_subject_scheme":"Other"},{"subitem_subject":"vitamin D receptor gene polymorphismz","subitem_subject_scheme":"Other"},{"subitem_subject":"bone mineral density","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hemodialysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"renal osteodystrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vitamin D receptor gene polymorphismz","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Association between Vitamin D Receptor Gene Polymorphisms and Renal Osteodystrophy in Patients on Maintenance Hemodialysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between Vitamin D Receptor Gene Polymorphisms and Renal Osteodystrophy in Patients on Maintenance Hemodialysis","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1088"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5153","relation_version_is_last":true,"title":["Association between Vitamin D Receptor Gene Polymorphisms and Renal Osteodystrophy in Patients on Maintenance Hemodialysis"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:57:06.046926+00:00"}