{"created":"2023-08-02T03:56:10.314650+00:00","id":5155,"links":{},"metadata":{"_buckets":{"deposit":"d2889425-71e2-411d-908b-241f4890a982"},"_deposit":{"created_by":10,"id":"5155","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5155"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005155","sets":["1:9","2:12","23:34:1087:1088"]},"author_link":["19140","19141","2381","19142","19143","19144","19145","19146","19147"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"57","bibliographicPageStart":"47","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"α-Fetoprotein (AFP) messenger RNA (mRNA) in the peripheral blood of patients with hepatocellular carcinoma (HCC) may indicate hematogenous spread of HCC. This study examined the presence of AFP mRNA in the blood of 148 patients, in terms of clinical parameters, tumor metastasis and survival rate. For the prospective study, 109 patients with HCC were followed in the period between March 1996 and March 1999. AFP mRNA in the blood was examined by means of nested reverse transcription polymerase chain reaction. AFP mRNA was detected in the blood in 23 (15.5%) of 148 patients with HCC. AFP mRNA in the blood was significantly correlated with protein induced by vitamin K absence or antagonist II level, higher AFP level (200 IU/mL or more) and extrahepatic metastases, but not with tumor size, number of tumor nodules or tumor-nodule-metastasis stage. This prospective study confirmed that intra- and extra-hepatic metastases developed more frequently in the 22 AFP mRNA-positive patients than in the 87 AFP mRNA-negative patients (P < 0.01). The cumulative survival rate was significantly lower in the former than in the latter (P < 0.01). In conclusion, AFP mRNA in the blood is closely related to hematogenous spread and might be a good predictor of metastasis and poorer survival rate in HCC patients.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 2000, 43(1), 47-57"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Clinical Laboratory Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Internal Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Internal Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Internal Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Department of Clinical Laboratory Medicine, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawakami, Manri"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koda, Masahiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murawaki, Yoshikazu"},{"creatorName":"Murawaki, Yoshikazu","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kawasaki, Hironaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikawa, Shiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawakami, Manri","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koda, Masahiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawasaki, Hironaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikawa, Shiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-08"}],"displaytype":"detail","filename":"43_047-057.pdf","filesize":[{"value":"114.4 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"43_047-057.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5155/files/43_047-057.pdf"},"version_id":"17899a0b-34e8-4019-ae08-85cf1254d6c3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-fetoprotein messenger RNA","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocellular carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"metastasis","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor marker","subitem_subject_scheme":"Other"},{"subitem_subject":"α-fetoprotein messenger RNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"metastasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor marker","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"α-Fetoprotein Messenger RNA in the Blood Predicts Poor Prognosis of the Patients with Hepatocellular Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α-Fetoprotein Messenger RNA in the Blood Predicts Poor Prognosis of the Patients with Hepatocellular Carcinoma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1088"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5155","relation_version_is_last":true,"title":["α-Fetoprotein Messenger RNA in the Blood Predicts Poor Prognosis of the Patients with Hepatocellular Carcinoma"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:57:12.748605+00:00"}