{"created":"2023-08-02T03:56:10.951490+00:00","id":5166,"links":{},"metadata":{"_buckets":{"deposit":"3d8e92c6-6c5d-4b4a-97f2-abeb3b060435"},"_deposit":{"created_by":10,"id":"5166","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5166"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005166","sets":["1:9","2:12","23:34:1091:1092"]},"author_link":["19194","19195","19196","19197","19198","19199"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dendritic cells (DCs) are one type of important inflammatory cells in the pathogenesis of asthma for early response to allergen exposure. Monocyte-derived DCs (MoDCs) are characterized by a high antigen uptake capacity and poor T-cell stimulatory activity, both features of immature DCs. By stimulation with tumor necrosis factor-alpha (TNF-alpha) or antigen capture, these cells differentiate into mature DCs with the disappearance of antigen-capturing regions, and increase in stimulatory activity. We measured the expression of some molecules on MoDCs before and after stimulation with TNF-alpha or house dust mite (HDM) antigen, from 9 house dust mite (HDM)-allergic asthmatic patients and 8 normal control subjects by flow cytometry. Primary MoDCs from HDM-allergic asthmatics showed a greater expression of histocompatibility leukocyte antigen (HLA)-DR and mannose receptor (MR), but not of CD80, CD86 or intercellular adhesion molecule-1 (ICAM-1), than those from normal subjects (P < 0.05). After stimulation with TNF-alpha or HDM, DCs from asthmatic patients showed a greater expression of HLA-DR, CD86 and ICAM-1, than those from normal subjects. In HDM-allergic asthmatic patients, MR expression on DCs significantly declined after stimulation by HDM compared with stimulation by TNF-alpha (P < 0.05). Results suggest that the reduction of MR expression may be characteristic on mature DCs after HDM exposure in allergic asthma.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 1999, 42(1), 1-10"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Third Department of Internal Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Third Department of Internal Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Third Department of Internal Medicine, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yajima, Hiroki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Katsuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hitsuda, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yajima, Hiroki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Katsuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hitsuda, Yutaka","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-05"}],"displaytype":"detail","filename":"42_001-010.pdf","filesize":[{"value":"70.9 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"42_001-010.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5166/files/42_001-010.pdf"},"version_id":"30a04f72-065e-458b-80bb-689ebcf5d9c7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"asthma","subitem_subject_scheme":"Other"},{"subitem_subject":"dendritic cells","subitem_subject_scheme":"Other"},{"subitem_subject":"histocompatibility leukocyte antigen-deoxyribose","subitem_subject_scheme":"Other"},{"subitem_subject":"house dust mite","subitem_subject_scheme":"Other"},{"subitem_subject":"mannose receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"asthma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dendritic cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histocompatibility leukocyte antigen-deoxyribose","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"house dust mite","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mannose receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1092"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5166","relation_version_is_last":true,"title":["Expression of Surface Markers on Mature Monocyte-Derived Dendritic Cells from Allergic Asthmatics"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:57:48.706771+00:00"}