@article{oai:repository.lib.tottori-u.ac.jp:00005179,
 author = {Utsunomiya, Yasushi and Konishi, Kyoko and Okada, Shin-ichi and Okada, Shin-ichi and Sasaki, Yoshihiro and Hayashi, Atsushi and Nakagawa, Takako and Kasagi, Tsunakiyo and Kasagi, Tsunakiyo and Shiraki, Kazuo and Shiraki, Kazuo and Utsunomiya, Yasushi and Konishi, Kyoko and Sasaki, Yoshihiro and Hayashi, Atsushi and Nakagawa, Takako},
 issue = {1},
 journal = {Yonago Acta medica, Yonago Acta medica},
 month = {Mar},
 note = {We report a 3-year-old girl with steroid resistant nephrotic syndrome (NS) who developed nephrotoxicity by low-dose cyclosporin (CsA) treatment. Initial prednisolone (PSL) treatment and subsequent additional cyclophosphamide treatment were not successful in leading her into remission. The first renal biopsy finding revealed neither a glomerular nor interstitial change. CsA therapy was initiated in addition to ongoing glucocorticoid therapy at 6 months from the time of onset. Proteinuria disappeared 3 weeks later and the patient went into complete remission. After experiencing the first relapse, the patient was gradually weaned from CsA, and treatment continued with 30 to 50 ng/mL of trough concentration. No elevations of the serum creatinine, serum urea, serum potassium, excretion of urinary β2-microglobulin, or urinary N-acetyl-β-D-glucosaminidase were demonstrated in the follow-up. A second renal biopsy specimen obtained 1 year later showed a tubulo-interstitial change, containing tubular atrophy and interstitial fibrosis, both of which are consistent with the morphological change associated with CsA nephrotoxicity. A follow-up biopsy should be done in order to evaluate the CsA nephrotoxicity, regardless of the treatment dosage.},
 pages = {125--130},
 title = {A Case of Nephrotic Syndrome with Nephrotoxicity Induced by Low-Dose Cyclosporin Treatment},
 volume = {42},
 year = {1999}
}