{"created":"2023-08-02T03:56:12.519046+00:00","id":5196,"links":{},"metadata":{"_buckets":{"deposit":"1a0ee95e-e3ad-414f-9d9e-fc737fd361d7"},"_deposit":{"created_by":10,"id":"5196","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5196"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005196","sets":["1:9","2:12","23:34:1095:1096"]},"author_link":["3524","19322","2488","2779","19323"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Yonago Acta medica"},{"bibliographic_title":"Yonago Acta medica","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Expression of major histocompatibility complex (MHC) antigens on cancer cells is essential for cell-mediated immune function. However, these molecules are reduced on cancer cells enabling them to escape from host immune surveillance. It is well known that interferon-γ (IFN-γ) upregulates the expression of MHC molecules and restores the immunogenicity of cancer cells. Nevertheless, the mechanism by which IFN-γ modulates MHC expression on cancer cells is not clear. Therefore, in this report, we examined the role of tyrosine protein kinases in IFN-γ-induced MHC expression in a human lung adenocarcinoma cell line, HLC-1. We found that a tyrosine protein kinase inhibitor, herbimycin A, inhibited both IFN-γ-inducible MHC class I and class II expression, as assessed by flow cytometry. Additionally, assessment of tyrosine phosphorylation of cellular substrates by confocal laser microscopy using an anti-phosphotyrosine monoclonal antibody (mAb) revealed that IFN-γ induced protein tyrosine phosphorylation within 5 min of treatment. Herbimycin A inhibited this IFN-γ-induced tyrosine phosphorylation. Thus, tyrosine phosphorylation plays an important role in IFN-γ-induced MHC class I and class II expression on HLC-1 cells.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tottori University Faculty of Medicine"}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yonago Acta medica. 1998, 41(1), 1-6"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Yonago Acta medica　編集委員会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00892882","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468049","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_32":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Second Department of Surgery, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Surgery, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Surgery, Faculty of Medicine, Tottori University"},{"subitem_text_value":"Second Department of Surgery, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Yoshimasa"},{"creatorName":"Suzuki, Yoshimasa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3524","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00335514","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00335514"},{"nameIdentifier":"100001959","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001959_ja.html"}]},{"creatorNames":[{"creatorName":"Tanaka, Yoshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"19322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Hiroshige"},{"creatorName":"Nakamura, Hiroshige","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2488","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30252852","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30252852"},{"nameIdentifier":"100000400","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000400_ja.html"}]},{"creatorNames":[{"creatorName":"Ohgi, Shigetsugu"},{"creatorName":"Ohgi, Shigetsugu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2779","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50168845","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50168845"}]},{"creatorNames":[{"creatorName":"Tanaka, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"19323","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2009-06-05"}],"displaytype":"detail","filename":"41_001-006.pdf","filesize":[{"value":"271.0 kB"}],"format":"application/pdf","licensefree":"Yonago Acta medica　編集委員会","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"41_001-006.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/5196/files/41_001-006.pdf"},"version_id":"cd5958f3-e558-4ead-b91f-33b3f99f9a8b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"human lung cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon-gamma","subitem_subject_scheme":"Other"},{"subitem_subject":"major histocompatibility complex","subitem_subject_scheme":"Other"},{"subitem_subject":"tyrosine phosphorylation","subitem_subject_scheme":"Other"},{"subitem_subject":"human lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon-gamma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"major histocompatibility complex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tyrosine phosphorylation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9","1096"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5196","relation_version_is_last":true,"title":["Tyrosine Phosphorylation Regulates the Expression of Major Histocompatibility Complex Antigens on a Human Lung Cancer Cell Line by Interferon-gamma"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-10-03T23:59:22.924009+00:00"}