{"created":"2023-08-02T03:56:48.619843+00:00","id":5843,"links":{},"metadata":{"_buckets":{"deposit":"2573ec99-1c6c-459b-b2b7-44513ee3295c"},"_deposit":{"created_by":10,"id":"5843","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5843"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005843","sets":["1:9","2:13","24:58"]},"author_link":["40028","40029"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-09-30"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鳥取大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epstein‑Barr virus‑associated gastric carcinoma (EBVaGC) is a distinct subtype of gastric cancer characterized by clinicopathological features including lymphoepithelioma‑like histology. Aberrant expression of activation‑induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen‑related nuclear factor κB (NF‑κB) signaling in Helicobacter pylori‑associated gastric cancer. To elucidate whether or not AID expression is relevant to carcinogenesis in EBVaGC, immunohistochemical expression of AID and AID‑regulatory factors between EBVaGC and EBV‑non‑associated gastric carcinoma (GC) were evaluated, each using 15 cases of GC with lymphoid stroma (GCLS) and other types of GC. Aberrant expression of AID, NF‑κB and paired box 5 (PAX5) were significantly decreased in EBVaGC (0/11, 1/11 and 1/11) compared with in EBV‑non‑associated GC (7/19, 12/19 and 11/19) (P=0.025, 0.005 and 0.01, respectively); however, no significant difference in c‑Myb proto‑oncogene expression was identified. AID expression was also decreased in EBV‑associated GCLS (0/10) compared with in EBV‑non‑associated GCLS (3/5). Unexpectedly, decreased expression of NF‑κB and PAX5 was observed in GCLS (1/15 and 2/15) compared with in GC without LS (12/15 and 10/15) (P<0.001 and P=0.003, respectively). Decreased AID expression observed in EBVaGC is consistent with the reported molecular characterization of hypermethylation and rare somatic gene mutation in EBVaGC. Only PAX5 was identified to be significantly associated with venous invasion (P=0.022). The results of the present study suggest that pathogen‑induced AID expression may be irrelevant to carcinogenesis of EBVaGC, whereas it contributes to carcinogenesis in certain types of EBV‑non‑associated GC.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第859号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"This research was published by Spandidos Publications: Mohri, T., Nagata, K., Kuwamoto, S., Matsushita, M., Sugihara, H., Kato, M. ... Hayashi, K. (2017). Aberrant expression of AID and AID activators of NF-κB and PAX5 is irrelevant to EBV-associated gast"}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://spandidos-publications.com/ol/13/6/4133"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://spandidos-publications.com/ol/13/6/4133","subitem_relation_type_select":"URI"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Mohri et al. This is an open access article distributed under the terms of Creative Commons Attribution License: CC-BY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"毛利, 崇"},{"creatorName":"モウリ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Takashi","creatorNameLang":"en"},{"creatorName":"モウリ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-24"}],"displaytype":"detail","filename":"G11_15101A00859.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensefree":"© Mohri et al. This is an open access article distributed under the terms of Creative Commons Attribution License: CC-BY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文 : Full Text","objectType":"fulltext","url":"https://repository.lib.tottori-u.ac.jp/record/5843/files/G11_15101A00859.pdf"},"version_id":"dd22e67c-2599-4652-b3b8-f7cea208dcfc"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-29"}],"displaytype":"detail","filename":"G11_15101A00859R.pdf","filesize":[{"value":"526.7 kB"}],"format":"application/pdf","licensefree":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨 : Summary","objectType":"abstract","url":"https://repository.lib.tottori-u.ac.jp/record/5843/files/G11_15101A00859R.pdf"},"version_id":"3d16157e-6428-41cf-92f1-f1e516503193"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-12-29"}],"displaytype":"detail","filename":"G11_15101A00859S.pdf","filesize":[{"value":"490.5 kB"}],"format":"application/pdf","licensefree":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果要旨 : Summary of Thesis Review","objectType":"abstract","url":"https://repository.lib.tottori-u.ac.jp/record/5843/files/G11_15101A00859S.pdf"},"version_id":"65ad7f31-3ca7-4a4d-b1dc-1851597ad36d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"activation-induced cytidine deaminase","subitem_subject_scheme":"Other"},{"subitem_subject":"Epstein-Barr virus-associated gastric cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"nuclear factor κB","subitem_subject_scheme":"Other"},{"subitem_subject":"paired box 5","subitem_subject_scheme":"Other"},{"subitem_subject":"c-Myb proto-oncogene","subitem_subject_scheme":"Other"},{"subitem_subject":"activation-induced cytidine deaminase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epstein-Barr virus-associated gastric cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nuclear factor κB","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"paired box 5","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"c-Myb proto-oncogene","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis"}]},"item_title":"AIDとAID活性化因子であるNF-kB、PAX5の異所性発現は、EBV関連胃癌とは関連しないが、一部のEBV非関連胃癌の発がんに関連する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"AIDとAID活性化因子であるNF-kB、PAX5の異所性発現は、EBV関連胃癌とは関連しないが、一部のEBV非関連胃癌の発がんに関連する","subitem_title_language":"ja"},{"subitem_title":"Aberrant expression of AID and AID activators of NF-kB and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"10","path":["13","9","58"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5843","relation_version_is_last":true,"title":["AIDとAID活性化因子であるNF-kB、PAX5の異所性発現は、EBV関連胃癌とは関連しないが、一部のEBV非関連胃癌の発がんに関連する"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-27T08:39:34.798479+00:00"}