{"created":"2023-08-02T03:56:50.052367+00:00","id":5869,"links":{},"metadata":{"_buckets":{"deposit":"273559a4-73e2-4e0f-912f-5ba2833eab3c"},"_deposit":{"created_by":10,"id":"5869","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"5869"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00005869","sets":["1:9","2:13","24:58"]},"author_link":["40042","40043"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-01"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"鳥取大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inhibition of NLRP3 inflammasome. Here, we investigated the potential antidepressant and anti-inflammatory effects of BHB on rats exposed to acute and chronic stress. We examined the influence of repeated BHB administration on depressive and anxiety behaviors in a rodent model of chronic unpredictable stress (CUS). Additionally, the influence of acute immobilization (IMM) stress and single BHB administration on hippocampal interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were assessed. Repeated administration of BHB attenuated CUS-induced depressive- and anxiety-related behaviors. IMM stress increased levels of IL-1β in the hippocampus, while a single pre-administration of BHB attenuated this increase. Although no effect was observed on hippocampal TNF-α levels after 1?h of IMM stress, a single BHB pre-administration reduced hippocampal TNF-α. Our previous report showed that the release of IL-1β and TNF-α caused by stress is tightly regulated by NLRP3 inflammasome. These findings demonstrate that BHB exerts antidepressant-like effects, possibly by inhibiting NLRP3-induced neuro-inflammation in the hippocampus, and that BHB may be a novel therapeutic candidate for the treatment of stress-related mood disorders.","subitem_description_type":"Other"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第877号"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"This research was published by Scientific Reports: YAMANASHI, Takehiko, et al. Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses. Scientific reports, 2017, 7.1: 7677. https://d"}]}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.nature.com/articles/s41598-017-08055-1"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/articles/s41598-017-08055-1","subitem_relation_type_select":"URI"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and th"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山梨, 豪彦"},{"creatorName":"ヤマナシ, タケヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"40042","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamanashi, Takehiro","creatorNameLang":"en"},{"creatorName":"ヤマナシ, タケヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"40043","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"G11_15101A00877.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensefree":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and th","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文 : Full Text","objectType":"fulltext","url":"https://repository.lib.tottori-u.ac.jp/record/5869/files/G11_15101A00877.pdf"},"version_id":"475f0e35-a051-4d5b-9744-4170842b19f4"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"G11_15101A00877R.pdf","filesize":[{"value":"522.1 kB"}],"format":"application/pdf","licensefree":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨 : Summary","objectType":"abstract","url":"https://repository.lib.tottori-u.ac.jp/record/5869/files/G11_15101A00877R.pdf"},"version_id":"7c8977de-d127-417d-a42f-4a8a010023fb"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-05-31"}],"displaytype":"detail","filename":"G11_15101A00877S.pdf","filesize":[{"value":"479.5 kB"}],"format":"application/pdf","licensefree":"注があるものを除き、この著作物は日本国著作権法により保護されています。 / This work is protected under Japanese Copyright Law unless otherwise noted.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査結果要旨 : Summary of Thesis Review","objectType":"abstract","url":"https://repository.lib.tottori-u.ac.jp/record/5869/files/G11_15101A00877S.pdf"},"version_id":"d207fe56-979b-46ff-960e-97d2d13c1937"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"内因性NLRP3インフラマソーム阻害剤であるベータヒドロキシ酪酸はストレスによって誘導される行動と炎症の応答性を減弱させる","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"内因性NLRP3インフラマソーム阻害剤であるベータヒドロキシ酪酸はストレスによって誘導される行動と炎症の応答性を減弱させる","subitem_title_language":"ja"},{"subitem_title":"Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"10","path":["13","9","58"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-06-22"},"publish_date":"2018-06-22","publish_status":"0","recid":"5869","relation_version_is_last":true,"title":["内因性NLRP3インフラマソーム阻害剤であるベータヒドロキシ酪酸はストレスによって誘導される行動と炎症の応答性を減弱させる"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-27T08:41:01.461873+00:00"}