@article{oai:repository.lib.tottori-u.ac.jp:00007082,
 author = {吉田, 雄一 and Yoshida, Yuichi and Ehara, Yuko and 山元, 修 and Yamamoto, Osamu and Ehara, Yuko and Koga, Monji and Imafuku, Shinichi},
 issue = {8},
 journal = {ACTA DERMATO-VENEREOLOGICA, ACTA DERMATO-VENEREOLOGICA},
 month = {Sep},
 note = {Neurofibromatosis 1 has various complications. To elucidate the frequency of neurofibromatosis 1-related major complications requiring medical intervention, a nationwide retrospective study was conducted of 3,530 patients with neurofibromatosis 1 registered from 2001 to 2014 in Japan. The ratio of certified patients requiring medical intervention (>stage 3) was 82%. Patients classified in the most severe grade experienced dermatological complications (71.8% of patients), neurological complications (38.1%) and bone complications (33.3%). In patients with dermatological manifestations, medical treatment was needed for cutaneous neurofibromas (58%), diffuse plexiform neurofibromas (31%) and malignant peripheral nerve sheath tumours (10%). Patients with neurological manifestations needed medical treatment mainly for brain tumours (53%) and intellectual disability (26%). Patients with bone manifestations needed medical treatment for pseudoarthrosis (9%), scoliosis (55%) and bone defects (16%). It is necessary for physicians to be aware of neurofibromatosis 1-related complications requiring medical intervention in order to provide appropriate care for patients with neurofibromatosis 1.},
 pages = {753--756},
 title = {Epidemiological Analysis of Major Complications Requiring Medical Intervention in Patients with Neurofibromatosis 1},
 volume = {98},
 year = {2018},
 yomi = {ヨシダ, ユウイチ and エハラ, ユウコ and ヤマモト, オサム and エハラ, ユウコ}
}