{"created":"2023-08-02T03:57:59.357808+00:00","id":7108,"links":{},"metadata":{"_buckets":{"deposit":"a6bb5077-2676-43bc-851c-c9d203302b45"},"_deposit":{"created_by":10,"id":"7108","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7108"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007108","sets":["1:9","2:12"]},"author_link":["26293","26294","2308","26295","26296"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08-14","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"274","bibliographicPageStart":"269","bibliographicVolumeNumber":"464","bibliographic_titles":[{"bibliographic_title":"Biochemical and biophysical research communications"},{"bibliographic_title":"Biochemical and biophysical research communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sox2 is a transcriptional factor expressed in neural stem cells. It is known that Sox2 regulates cell differentiation, proliferation and survival of the neural stem cells. Our previous study showed that Sox2 is expressed in all satellite glial cells of the adult rat dorsal root ganglion. In this study, to examine the role of Sox2 in satellite glial cells, we establish a satellite glial cell-enriched culture system. Our culture method succeeded in harvesting satellite glial cells with the somata of neurons in the dorsal root ganglion. Using this culture system, Sox2 was downregulated by siRNA against Sox2. The knockdown of Sox2 downregulated ErbB2 and ErbB3 mRNA at 2 and 4 days after siRNA treatment. MAPK phosphorylation, downstream of ErbB, was also inhibited by Sox2 knockdown. Because ErbB2 and ErbB3 are receptors that support the survival of glial cells in the peripheral nervous system, apoptotic cells were also counted. TUNEL-positive cells increased at 5 days after siRNA treatment. These results suggest that Sox2 promotes satellite glial cell survival through the MAPK pathway via ErbB receptors.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Inc."}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2015.06.141","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Koike T., Wakabayashi T., Mori T., Hirahara Y., Yamada H. Sox2 promotes survival of satellite glial cells in vitro. Biochemical and Biophysical Research Communications(2015), 464 (1) , pp. 269-274."}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.sciencedirect.com/science/article/pii/S0006291X15301959"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S0006291X15301959","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2015 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00564395","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"}]},"item_10001_text_34":{"attribute_name":"雑誌内区分","attribute_value_mlt":[{"subitem_text_value":"Short communication"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koike, Taro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakabayashi, Taketoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Tetsuji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Hirahara, Yukie","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Hisao","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"bbrc646(1)_269.pdf","filesize":[{"value":"515.8 kB"}],"format":"application/pdf","licensefree":"Copyright © 2015 Elsevier Inc. All rights reserved. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"bbrc646(1)_269.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7108/files/bbrc646(1)_269.pdf"},"version_id":"581604d4-e72e-4159-930b-24990fb7e8d7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sox2","subitem_subject_scheme":"Other"},{"subitem_subject":"Satellite glial cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Culture","subitem_subject_scheme":"Other"},{"subitem_subject":"ErbB","subitem_subject_scheme":"Other"},{"subitem_subject":"Sox2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Satellite glial cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Culture","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ErbB","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Sox2 promotes survival of satellite glial cells in vitro","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sox2 promotes survival of satellite glial cells in vitro","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-15"},"publish_date":"2020-01-15","publish_status":"0","recid":"7108","relation_version_is_last":true,"title":["Sox2 promotes survival of satellite glial cells in vitro"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:33:39.112421+00:00"}