{"created":"2023-08-02T03:58:03.377927+00:00","id":7187,"links":{},"metadata":{"_buckets":{"deposit":"6dbbdb09-cf96-429c-bf5f-69f6154426b6"},"_deposit":{"created_by":10,"id":"7187","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7187"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007187","sets":["1:9","2:12"]},"author_link":["2308","26596","26597","26598","26599","26600"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"3193","bibliographicPageStart":"3184","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"European journal of neuroscience"},{"bibliographic_title":"European journal of neuroscience","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adult neurogenesis in the subgranular zone of the hippocampus (SGZ) is enhanced by excess as well as mild neuronal excitation, such as chemoconvulsant‐induced brief seizures. Because most studies of neurogenesis after seizures have focused on the SGZ, the threshold of neuronal excitation required to enhance neurogenesis in the subventricular zone (SVZ) is not clear. Therefore, we examined the responses of SVZ precursors to brief generalized clonic seizures induced by a single administration of the chemoconvulsant pentylenetetrazole (PTZ). Cell cycle progression of precursors was analysed by systemic administration of thymidine analogues. We found that brief seizures immediately resulted in cell cycle retardation in the SVZ. However, the same effect was not seen in the SGZ. This initial cell cycle retardation in the SVZ was followed by enhanced cell cycle re‐entry after the first round of mitosis, leading to precursor pool expansion, but the cell cycle retardation and expansion of the precursor pool were transient. Cell cycle progression in the PTZ‐treated group returned to normal after one cell cycle. The numbers of precursors in the SVZ and new neurons in the olfactory bulb, which are descendants of SVZ precursors, were not significantly different from those in control mice more than 2 days after seizures. Because similar effects were observed following electroconvulsive seizures, these responses are likely to be general effects of brief seizures. These results suggest that neurogenesis in the SVZ is more tightly regulated and requires stronger stimuli to be modified than that in the SGZ.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Federation of European Neuroscience Societies and Blackwell Publishing Ltd"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/j.1460-9568.2012.08244.x","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"This is the pre-peer reviewed version of the following article: Mori, T., Wakabayashi, T., Hirahara, Y., Takamori, Y., Koike, T., Kurokawa, K. and Yamada, H. (2012), Differential responses of endogenous adult mouse neural precursors to excess neuronal exc"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://onlinelibrary.wiley.com/doi/full/10.1111/j.1460-9568.2012.08244.x"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/full/10.1111/j.1460-9568.2012.08244.x","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11622970","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"14609568","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy & Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy & Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy & Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy & Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy & Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy & Cell Science, Kansai Medical University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mori, Tetsuji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Wakabayashi, Taketoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirahara, Yukie","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takamori, Yasuharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kurokawa, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Hisao","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"ejn36(9)_3184.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensefree":"© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ejn36(9)_3184.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7187/files/ejn36(9)_3184.pdf"},"version_id":"d61d7282-8f77-428c-916a-da317aa15d05"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adult mouse SVZ","subitem_subject_scheme":"Other"},{"subitem_subject":"cell cycle","subitem_subject_scheme":"Other"},{"subitem_subject":"neurogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"precursor","subitem_subject_scheme":"Other"},{"subitem_subject":"seizure","subitem_subject_scheme":"Other"},{"subitem_subject":"adult mouse SVZ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell cycle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"precursor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"seizure","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-08"},"publish_date":"2020-01-08","publish_status":"0","recid":"7187","relation_version_is_last":true,"title":["Differential responses of endogenous adult mouse neural precursors to excess neuronal excitation"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:38:09.366470+00:00"}