{"created":"2023-08-02T03:58:03.743747+00:00","id":7195,"links":{},"metadata":{"_buckets":{"deposit":"ac0d6775-5019-444b-b0ba-fe36eb5a418b"},"_deposit":{"created_by":10,"id":"7195","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7195"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007195","sets":["1:9","2:12"]},"author_link":["2371","4921"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-19","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"FRONTIERS IN IMMUNOLOGY"},{"bibliographic_title":"FRONTIERS IN IMMUNOLOGY","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In allergic contact dermatitis (ACD) and contact hypersensitivity (CHS), the healed skin shows greater swelling than the naïve skin in the same individual upon re-exposure to the same hapten. This “local skin memory” (LSM) in healed skin was maintained for a prolonged period of time and mediated by skin CD8+-resident memory T (TRM) cells in C57BL/6 mice. However, the number of CD4+ T cells is elevated in ACD-healed human skin, and the contribution of CD4+ TRM cells to the formation of LSM currently remains unclear. We herein demonstrated that immediately after CHS subsided, the healed skin in BALB/c mice showed an accumulation of hapten-specific CD4+ and CD8+ TRM cells, with a predominance of CD4+ TRM cells. The presence of CD4+ or CD8+ TRM cells in the healed skin was sufficient for the induction of a flare-up reaction upon a re-challenge. The CD4+ and CD8+ TRM cells both produced interferon-g and tumor necrosis factor early after the re-challenge. Moreover, while CD8+ TRM cells gradually decreased over time and were eventually lost from the healed skin at 40–51 weeks after the resolution of CHS, the CD4+ TRM cell numbers remained elevated during this period. The present results indicate that the long-term maintenance of LSM is mediated by CD4+ TRM cells, and thus CD4+ TRM cells are an important target for the treatment of recurrent human ACD.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Union of Immunological Societies"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3389/fimmu.2020.00775","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Murata Akihiko, Hayashi Shin-Ichi. CD4(+) Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice. FRONTIERS IN IMMUNOLOGY. 2020. 11. doi:10.3389/fimmu.2020.00775"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.00775/full"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.00775/full","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2020 Murata and Hayashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and th"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"16643224","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村田, 暁彦"},{"creatorName":"ムラタ, アキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Murata, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2371","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90624221","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90624221"},{"nameIdentifier":"100000266","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000266_ja.html"}]},{"creatorNames":[{"creatorName":"林, 眞一"},{"creatorName":"ハヤシ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Shin-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4921","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50208617","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50208617"},{"nameIdentifier":"100000221","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000221_ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"fi_fimmu_2020_00775.pdf","filesize":[{"value":"4.3 MB"}],"format":"application/pdf","licensefree":"Copyright © 2020 Murata and Hayashi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and th","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"fi_fimmu_2020_00775.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7195/files/fi_fimmu_2020_00775.pdf"},"version_id":"79969e41-1f95-4daa-be26-e4531c415a7a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tissue-resident memory T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"helper T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"killer T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"local skin memory","subitem_subject_scheme":"Other"},{"subitem_subject":"contact hypersensitivity","subitem_subject_scheme":"Other"},{"subitem_subject":"allergic contact dermatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"tissue-resident memory T cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"helper T cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"killer T cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"local skin memory","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"contact hypersensitivity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"allergic contact dermatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"CD4(+) Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CD4(+) Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-24"},"publish_date":"2021-11-24","publish_status":"0","recid":"7195","relation_version_is_last":true,"title":["CD4(+) Resident Memory T Cells Mediate Long-Term Local Skin Immune Memory of Contact Hypersensitivity in BALB/c Mice"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:38:37.950324+00:00"}