{"created":"2023-08-02T03:58:03.966357+00:00","id":7200,"links":{},"metadata":{"_buckets":{"deposit":"a23556c4-cfa0-4d79-8b7d-d17d0c91e66b"},"_deposit":{"created_by":10,"id":"7200","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7200"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007200","sets":["1:9","2:12"]},"author_link":["2308","26671","26672","26673","26674","26675"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"34","bibliographicPageStart":"21","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Glia"},{"bibliographic_title":"Glia","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Astrocytes are thought to play a variety of key roles in the adult brain, such as their participation in synaptic transmission, in wound healing upon brain injury, and adult neurogenesis. However, to elucidate these functions in vivo has been difficult because of the lack of astrocyte‐specific gene targeting. Here we show that the inducible form of Cre (CreERT2) expressed in the locus of the astrocyte‐specific glutamate transporter (GLAST) allows precisely timed gene deletion in adult astrocytes as well as radial glial cells at earlier developmental stages. Moreover, postnatal and adult neurogenesis can be targeted at different stages with high efficiency as it originates from astroglial cells. Taken together, this mouse line will allow dissecting the molecular pathways regulating the diverse functions of astrocytes as precursors, support cells, repair cells, and cells involved in neuronal information processing. © 2006 Wiley‐Liss, Inc.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley‐Liss, Inc."}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/glia.20350","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"This is the peer reviewed version of the following article: Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R. and Götz, M. (2006), Inducible gene deletion in astroglia and radial glia—A valuable tool for functional and lineage analysis. Glia, 54: 21-34"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://onlinelibrary.wiley.com/doi/full/10.1002/glia.20350"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/full/10.1002/glia.20350","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2006 Wiley‐Liss, Inc."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11620396","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10981136","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute of Stem Cell Research, GSF‐National Research Center for Environment and Health"},{"subitem_text_language":"en","subitem_text_value":"Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute Tokyo Medical and Dental University"},{"subitem_text_language":"en","subitem_text_value":"Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute Tokyo Medical and Dental University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Developmental Genetics, GSF-National Research Center for Environment and Health,"},{"subitem_text_language":"en","subitem_text_value":"Institute of Developmental Genetics, GSF-National Research Center for Environment and Health"},{"subitem_text_language":"en","subitem_text_value":"GSF - National Research Center for Environment and Health / Department of Physiology, Ludwig-Maximilians University"}]},"item_10001_text_34":{"attribute_name":"雑誌内区分","attribute_value_mlt":[{"subitem_text_value":"Original Article"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mori, Tetsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2308","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30285043","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30285043"},{"nameIdentifier":"100001237","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001237_ja.html"}]},{"creatorNames":[{"creatorName":"Tanaka, Kohichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Buffo, Annalisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kühn, Ralf","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wurst, Wolfgang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Goetz, Magdalena","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26675","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"g54(1)_21.pdf","filesize":[{"value":"7.7 MB"}],"format":"application/pdf","licensefree":"Copyright © 2006 Wiley‐Liss, Inc.","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"g54(1)_21.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7200/files/g54(1)_21.pdf"},"version_id":"b0eed273-6f32-4f32-91a5-f83ce72c1833"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GLAST","subitem_subject_scheme":"Other"},{"subitem_subject":"CreERT2","subitem_subject_scheme":"Other"},{"subitem_subject":"inducible cre activity","subitem_subject_scheme":"Other"},{"subitem_subject":"radial glia","subitem_subject_scheme":"Other"},{"subitem_subject":"astrocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"adult neurogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"GLAST","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CreERT2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"inducible cre activity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"radial glia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"astrocyte","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adult neurogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inducible gene deletion in astroglia and radial glia : A valuable tool for functional and lineage analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inducible gene deletion in astroglia and radial glia : A valuable tool for functional and lineage analysis","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-08"},"publish_date":"2020-01-08","publish_status":"0","recid":"7200","relation_version_is_last":true,"title":["Inducible gene deletion in astroglia and radial glia : A valuable tool for functional and lineage analysis"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:38:57.409027+00:00"}