{"created":"2023-08-02T03:58:04.228535+00:00","id":7206,"links":{},"metadata":{"_buckets":{"deposit":"acb9ec70-50de-4b52-b1cf-25543cf8ea6f"},"_deposit":{"created_by":10,"id":"7206","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7206"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007206","sets":["1:9","2:12"]},"author_link":["26702","26703","26704","2308","26705","26706","26707","26708","26709","26710"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-11-05","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"109","bibliographicPageStart":"99","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"IBRO Reports"},{"bibliographic_title":"IBRO Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lamins are type V intermediate filament proteins that are located beneath the inner nuclear membrane. In mammalian somatic cells, LMNB1 and LMNB2 encode somatic lamins B1 and B2, respectively, and the LMNA gene is alternatively spliced to generate somatic lamins A and C. Mutations in lamin genes have been linked to many human hereditary diseases, including neurodegenerative disorders. Knowledge about lamins in the nervous system has been accumulated recently, but a precise analysis of lamin subtypes in glial cells has not yet been reported. In this study we investigated the composition of lamin subtypes in neurons, astrocytes, oligodendrocyte-lineage cells, and microglia in the adult rat cerebral cortex using an immunohistochemical staining method. Lamin A was not observed in neurons and glial cells. Lamin C was observed in astrocytes, mature oligodendrocytes and neurons, but not observed in oligodendrocyte progenitor cells. Microglia also did not stain positive for lamin C which differed from macrophages, with lamin C positive. Lamin B1 and B2 were observed in all glial cells and neurons. Lamin B1 was intensely positive in oligodendrocyte progenitor cells compared with other glial cells and neurons. Lamin B2 was weakly positive in all glial cells compared to neurons. Our current study might provide useful information to reveal how the onset mechanisms of human neurodegenerative diseases are associated with mutations in genes for nuclear lamin proteins.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ibror.2018.11.001","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"TAKAMORI, Yasuharu, et al. Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex. IBRO reports, 2018, 5: 99-109."}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.sciencedirect.com/science/article/pii/S2451830118300578"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S2451830118300578","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2018 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"24518301","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University / Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"},{"subitem_text_language":"en","subitem_text_value":"Laboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research / Multi-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center"},{"subitem_text_language":"en","subitem_text_value":"Laboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research / Multi-Modal Microstructure Analysis Unit, RIKEN-JEOL Collaboration Center"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University / Department of School Education Research, Shizuoka University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University / Department of Human Health Science, Osaka international University"},{"subitem_text_language":"en","subitem_text_value":"Department of Anatomy and Cell Science, Kansai Medical University"}]},"item_10001_text_34":{"attribute_name":"雑誌内区分","attribute_value_mlt":[{"subitem_text_value":"Research article"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takamori, Yasuharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirahara, Yukie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakabayashi, Taketoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Tetsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2308","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30285043","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30285043"},{"nameIdentifier":"100001237","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001237_ja.html"}]},{"creatorNames":[{"creatorName":"Koike, Taro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kataoka, Yosky","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamura, Yasuhisa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurebayashi, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurokawa, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Hisao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26710","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"ibror5_99.pdf","filesize":[{"value":"13.2 MB"}],"format":"application/pdf","licensefree":"© 2018 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ibror5_99.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7206/files/ibror5_99.pdf"},"version_id":"a2836a83-4811-4c86-83b4-bd76b0b97691"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Lamins","subitem_subject_scheme":"Other"},{"subitem_subject":"Neurons","subitem_subject_scheme":"Other"},{"subitem_subject":"Glial cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Adult rat","subitem_subject_scheme":"Other"},{"subitem_subject":"Cerebral cortex","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"Lamins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neurons","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glial cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adult rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cerebral cortex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-16"},"publish_date":"2020-01-16","publish_status":"0","recid":"7206","relation_version_is_last":true,"title":["Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:39:14.937629+00:00"}