{"created":"2023-08-02T03:58:04.549074+00:00","id":7213,"links":{},"metadata":{"_buckets":{"deposit":"84611a7c-3565-4d07-913e-c018c4dea10a"},"_deposit":{"created_by":10,"id":"7213","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7213"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007213","sets":["1:9","2:12"]},"author_link":["2371","4680","4921","26729","26730"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"79","bibliographicPageStart":"69","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"INTERNATIONAL IMMUNOLOGY"},{"bibliographic_title":"INTERNATIONAL IMMUNOLOGY","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Kit/CD117 plays a crucial role in the cell–cell and cell–matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs. In the present study, we show a novel Kit-independent adhesion mechanism of mouse cultured MCs mediated by Notch family members. On stromal cells transduced with each Notch ligand gene, Kit and its signaling become dispensable for the entire adhesion process of MCs from tethering to spreading. The Notch-mediated spreading of adherent MCs involves the activation of signaling via phosphatidylinositol 3-kinases and mitogen-activated protein kinases, similar to Kit-mediated spreading. Despite the activation of the same signaling pathways, while Kit supports the adhesion and survival of MCs, Notch only supports adhesion. Thus, Notch family members are specialized adhesion molecules for MCs that effectively replace the adhesion function of Kit in order to support the interaction of MCs with the surrounding cellular microenvironments.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/intimm/dxy067","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Murata Akihiko, Hikosaka Mari, Yoshino Miya, et al. Kit-independent mast cell adhesion mediated by Notch. INTERNATIONAL IMMUNOLOGY. 2019. 31(2). 69-79. doi:10.1093/intimm/dxy067"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://academic.oup.com/intimm/article/31/2/69/5123694"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/intimm/article/31/2/69/5123694","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is a pre-copyedited, author-produced version of an article accepted for publication in INTERNATIONAL IMMUNOLOGY following peer review. The version of record Akihiko Murata, Mari Hikosaka, Miya Yoshino, Lan Zhou, Shin-Ichi Hayashi, Kit-independent mas"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09538178","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"14602377"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Pathology, Case Western Reserve University"},{"subitem_text_language":"en","subitem_text_value":"Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村田, 暁彦"},{"creatorName":"ムラタ, アキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Murata, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2371","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90624221","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90624221"},{"nameIdentifier":"100000266","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000266_ja.html"}]},{"creatorNames":[{"creatorName":"吉野, 三也"},{"creatorName":"ヨシノ, ミヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshino, Miya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4680","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000285","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000285_ja.html"}]},{"creatorNames":[{"creatorName":"林, 眞一"},{"creatorName":"ハヤシ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Hayashi, Shin-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4921","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50208617","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50208617"},{"nameIdentifier":"100000221","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000221_ja.html"}]},{"creatorNames":[{"creatorName":"Hikosaka, Mari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhou, Lan","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26730","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"ii31(2)_69.pdf","filesize":[{"value":"7.5 MB"}],"format":"application/pdf","licensefree":"This is a pre-copyedited, author-produced version of an article accepted for publication in INTERNATIONAL IMMUNOLOGY following peer review. 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