@article{oai:repository.lib.tottori-u.ac.jp:00007224, author = {Koizumi, Ryo and Azuma, Kazuo and Izawa, Hironori and Morimoto, Minoru and Ochi, Kosuke and Tsuka, Takeshi and Imagawa, Tomohiro and Osaki, Tomohiro and Ito, Norihiko and Okamoto, Yoshiharu and Saimoto, Hiroyuki and Ifuku, Shinsuke}, issue = {2}, journal = {International Journal of Molecular Sciences, International Journal of Molecular Sciences}, month = {Jan}, note = {This study investigated the prophylactic effects of orally administered surface-deacetylated chitin nanofibers (SDACNFs) and chitosan against 5-fluorouracil (5-FU)-induced intestinal mucositis, which is a common side effect of 5-FU chemotherapy. SDACNFs and chitosan abolished histological abnormalities associated with intestinal mucositis and suppressed hypoproliferation and apoptosis of intestinal crypt cells. These results indicate that SDACNF and chitosan are useful agents for preventing mucositis induced by anti-cancer drugs.}, title = {Oral Administration of Surface-Deacetylated Chitin Nanofibers and Chitosan Inhibit 5-Fluorouracil-Induced Intestinal Mucositis in Mice}, volume = {18}, year = {2017} }