{"created":"2023-08-02T03:58:05.165855+00:00","id":7227,"links":{},"metadata":{"_buckets":{"deposit":"35e9d0b7-1a3d-4c7b-a369-bd623b296231"},"_deposit":{"created_by":10,"id":"7227","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7227"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007227","sets":["1:9","2:12"]},"author_link":["4866","95","780","377","3368","26772"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"22","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES"},{"bibliographic_title":"INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Unconventional prefoldin RNA polymerase II subunit 5 interactor (URI1) has emerged as an oncogenic driver in hepatocellular carcinoma (HCC). Although the hepatitis B virus (HBV) represents the most common etiology of HCC worldwide, it is unknown whether URI1 plays a role in HBV-related HCC (HCC-B). In the present study, we investigated URI1 expression and its underlying mechanism in HCC-B tissues and cell lines. URI1 gene-promoter activity was determined by a luciferase assay. Human HCC-B samples were used for a chromatin immunoprecipitation assay. We found that c-MYC induced URI1 expression and activated the URI1 promoter through the E-box in the promoter region while the HBx protein significantly enhanced it. The positivity of URI1 expression was significantly higher in HCC-B tumor tissues than in non-HBV-related HCC tumor tissues, suggesting that a specific mechanism underlies URI1 expression in HCC-B. In tumor tissues from HCC-B patients, a significantly higher level of c-MYC was recruited to the E-box than in non-tumor tissues. These results suggest that HBx and c-MYC are involved in URI1 expression in HCC-B. URI1 expression may play important roles in the development and progression of HCC-B because HBx and c-MYC are well-known oncogenic factors in the virus and host, respectively.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms20225714","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Tsuchiya Hiroyuki, Amisaki Masataka, Takenaga Ai, et al. HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019. 20(22). doi:10.3390/ijms20225714"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.mdpi.com/1422-0067/20/22/5714"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/1422-0067/20/22/5714","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"14220067"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土谷, 博之"},{"creatorName":"ツチヤ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchiya, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4866","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00403402","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00403402"},{"nameIdentifier":"100001720","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001720_ja.html"}]},{"creatorNames":[{"creatorName":"網崎, 正孝"},{"creatorName":"アミサキ, マサタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Amisaki, Masataka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"95","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40790374","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40790374"}]},{"creatorNames":[{"creatorName":"本城, 総一郎"},{"creatorName":"ホンジョウ, ソウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Honjo, Soichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"780","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000247","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000247_ja.html"}]},{"creatorNames":[{"creatorName":"藤原, 義之"},{"creatorName":"フジワラ, ヨシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujiwara, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"377","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40314330","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40314330"},{"nameIdentifier":"100001755","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001755_ja.html"}]},{"creatorNames":[{"creatorName":"汐田, 剛史"},{"creatorName":"シオタ, ゴウシ","creatorNameLang":"ja-Kana"},{"creatorName":"Shiota, Goshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3368","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70263457","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70263457"},{"nameIdentifier":"100000303","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000303_ja.html"}]},{"creatorNames":[{"creatorName":"Takenaga, Ai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26772","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"ijms20_ijms20225714.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensefree":"© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ijms20_ijms20225714.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7227/files/ijms20_ijms20225714.pdf"},"version_id":"3ef73897-a37e-4e4c-958a-8b4a0cad1cd7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"URI1","subitem_subject_scheme":"Other"},{"subitem_subject":"HBx","subitem_subject_scheme":"Other"},{"subitem_subject":"c-MYC","subitem_subject_scheme":"Other"},{"subitem_subject":"HBV-related hepatocellular carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"E-box","subitem_subject_scheme":"Other"},{"subitem_subject":"URI1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HBx","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"c-MYC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HBV-related hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"E-box","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-08"},"publish_date":"2021-09-08","publish_status":"0","recid":"7227","relation_version_is_last":true,"title":["HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:40:17.889546+00:00"}