{"created":"2023-08-02T03:58:05.250794+00:00","id":7229,"links":{},"metadata":{"_buckets":{"deposit":"f19ca078-3df8-4e9a-adf0-e7d55b7e6fe2"},"_deposit":{"created_by":10,"id":"7229","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7229"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007229","sets":["1:9","2:12"]},"author_link":["3618","3446","1986","26781","396","1082","26782","26783","26784","26785","26786","26787","26788","26789"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES"},{"bibliographic_title":"INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH) are major health burdens closely related to metabolic syndrome. A link between CKD and NASH has been assumed; however, the underlying mechanism is still unknown. Ectopic lipid deposition (ELD) in the hepatocyte results in endoplasmic reticulum (ER) stress, which plays an important role in the development of steatohepatitis. ELD is also assumed to play a role in the development of kidney injury. We aimed to investigate the role of ELD and ER stress in the development of CKD, and evaluate the efficacy of a sodium glucose cotransporter-2 inhibitor, ipragliflozin. Methods: Male FLS-ob/ob mice that closely imitate the pathophysiology of NASH were treated with vehicle or ipragliflozin. Metabolic characteristics, histology of the kidney, ER stress, and apoptotic signals were evaluated. Results: The serum triglyceride was significantly lower in mice treated with ipragliflozin. Ipragliflozin reduced ELD in renal tubules. Ipragliflozin also reduced the expression levels of GRP78 and CHOP, apoptotic cells, and interstitial fibrosis. Conclusions: ELD induced kidney injury through ER stress. Ipragliflozin improved the pathogenesis of CKD by reducing ELD and ER stress in NASH-model mice. Our results suggest ipragliflozin has therapeutic effect on CKD in NASH.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms21010190","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Hosokawa Kohshiro, Takata Tomoaki, Sugihara Takaaki, et al. Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020. 21(1). doi:10"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.mdpi.com/1422-0067/21/1/190"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/1422-0067/21/1/190","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12038549","subitem_source_identifier_type":"NCID"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"14220067"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University / These authors contributed equally to this work."},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University / These authors contributed equally to this work."},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Hino Hospital"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高田, 知朗"},{"creatorName":"タカタ, トモアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Takata, Tomoaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3618","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100001163","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001163_ja.html"}]},{"creatorNames":[{"creatorName":"杉原, 誉明"},{"creatorName":"スギハラ, タカアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugihara, Takaaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3446","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60753853","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60753853"},{"nameIdentifier":"100001245","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001245_ja.html"}]},{"creatorNames":[{"creatorName":"的野, 智光"},{"creatorName":"マトノ, トモミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Matono, Tomomitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1986","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60571841","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60571841"},{"nameIdentifier":"100001319","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001319_ja.html"}]},{"creatorNames":[{"creatorName":"Koda, Masahiko"},{"creatorName":"コウダ, マサヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"26781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福田, 佐登子"},{"creatorName":"フクダ, サトコ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Satoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"396","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000933","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000933_ja.html"}]},{"creatorNames":[{"creatorName":"磯本, 一"},{"creatorName":"イソモト, ハジメ","creatorNameLang":"ja-Kana"},{"creatorName":"Isomoto, Hajime","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1082","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90322304","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90322304"},{"nameIdentifier":"100001541","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100001541_ja.html"}]},{"creatorNames":[{"creatorName":"Hosokawa, Kohshiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koda, Masahiko","creatorNameLang":"en"},{"creatorName":"コウダ, マサヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"26783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanda, 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