{"created":"2023-08-02T03:58:06.526671+00:00","id":7256,"links":{},"metadata":{"_buckets":{"deposit":"e5799172-8a67-49ce-98f0-b91f781dd2db"},"_deposit":{"created_by":10,"id":"7256","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7256"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007256","sets":["1:9","2:12"]},"author_link":["349","2790","26919","2090","1167","1364","3805","4288","26920","26921","26922","26923"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"278","bibliographicPageStart":"274","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF DIABETES INVESTIGATION"},{"bibliographic_title":"JOURNAL OF DIABETES INVESTIGATION","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims/Introduction: The aim of the present study was to evaluate the properties of the glucagon stimulation test (GST) and the normal meal tolerance test (NMTT) in patients with type 2 diabetes. Materials and Methods: We enrolled 142 patients with type 2 diabetes, and carried out a GST and a NMTT. We carried out the NMTT using a calorie-controlled meal based on an intake of 30 kcal/kg ideal bodyweight/day. We calculated the change in C-peptide immunoreactivity (ΔCPR) by subtracting fasting CPR from the CPR 6 min after the 1-mg glucagon injection (GST) or 120 min after the meal (NMTT). Results: Mean ΔCPR for the GST was 2.0 ng/mL, and for the NMTT was 3.1 ng/mL. A total of 104 patients had greater ΔCPR in the NMTT than the GST, and the mean ΔCPR was significantly greater in the NMTT than the GST (P < 0.05). To exclude any influence of antidiabetic drugs, we examined 42 individuals not taking antidiabetic agents, and found the mean ΔCPR was significantly greater in the NMTT than the GST (GST 2.4 ng/mL, NMTT 4.3 ng/mL; P < 0.05). To consider the influence of glucose toxicity, we carried out receiver operating characteristic analyses with fasting plasma glucose and glycated hemoglobin. The optimal cut-off levels predicting GST ΔCPR to be larger than NMTT ΔCPR were fasting plasma glucose 147 mg/dL and glycated hemoglobin 9.0% (fasting plasma glucose: sensitivity 0.64, specificity 0.76, area under the curve 0.73; glycated hemoglobin: sensitivity 0.56, specificity 0.71, area under the curve 0.66). Conclusions: The NMTT is a reliable insulin secretion test in patients with type 2 diabetes, except for those in a hyperglycemic state.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/jdi.12692","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Fujioka Youhei, Okura Tsuyoshi, Sumi Keisuke, et al. Normal meal tolerance test is preferable to the glucagon stimulation test in patients with type 2 diabetes that are not in a hyperglycemic state: Comparison with the change of C-peptide immunoreactivity"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://onlinelibrary.wiley.com/doi/full/10.1111/jdi.12692"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/full/10.1111/jdi.12692","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd J Diabetes Investig Vol. No      2017 This is an open access article under the terms of the Creati"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20401116","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"20401124"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Regional Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Regional Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤岡, 洋平"},{"creatorName":"フジオカ, ヨウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujioka, Youhei","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"大倉, 毅"},{"creatorName":"オオクラ, ツヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Okura, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"角, 啓佑"},{"creatorName":"スミ, ケイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松澤, 和彦"},{"creatorName":"マツザワ, カズヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuzawa, Kazuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊澤, 正一郎"},{"creatorName":"イザワ, ショウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Izawa, Shoichiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"加藤, 雅彦"},{"creatorName":"カトウ, マサヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Masahiko","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"谷口, 晋一"},{"creatorName":"タニグチ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Taniguchi, Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"山本, 一博"},{"creatorName":"ヤマモト, カズヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sumi, Keisuke","creatorNameLang":"en"},{"creatorName":"スミ, ケイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Kazuhisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shoji, Kyoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Risa","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"jdi9(2)_274.pdf","filesize":[{"value":"320.1 kB"}],"format":"application/pdf","licensefree":"(C) 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd J Diabetes Investig Vol. No      2017 This is an open access article under the terms of the Creati","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jdi9(2)_274.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7256/files/jdi9(2)_274.pdf"},"version_id":"658294d7-ad0a-4cc6-bd28-b5e982eac71c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"C-peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucagon stimulation test","subitem_subject_scheme":"Other"},{"subitem_subject":"Meal tolerance test","subitem_subject_scheme":"Other"},{"subitem_subject":"C-peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucagon stimulation test","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Meal tolerance test","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Normal meal tolerance test is preferable to the glucagon stimulation test in patients with type 2 diabetes that are not in a hyperglycemic state: Comparison with the change of C-peptide immunoreactivity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Normal meal tolerance test is preferable to the glucagon stimulation test in patients with type 2 diabetes that are not in a hyperglycemic state: Comparison with the change of C-peptide immunoreactivity","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-15"},"publish_date":"2021-09-15","publish_status":"0","recid":"7256","relation_version_is_last":true,"title":["Normal meal tolerance test is preferable to the glucagon stimulation test in patients with type 2 diabetes that are not in a hyperglycemic state: Comparison with the change of C-peptide immunoreactivity"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:42:02.786283+00:00"}