@article{oai:repository.lib.tottori-u.ac.jp:00007257,
 author = {大倉, 毅 and Okura, Tsuyoshi and 藤岡, 洋平 and Fujioka, Yohei and 角, 啓佑 and 松澤, 和彦 and Matsuzawa, Kazuhiko and 伊澤, 正一郎 and Izawa, Shoichiro and 大塚, 譲 and Otsuka, Yuzuru and 加藤, 雅彦 and Kato, Masahiko and 谷口, 晋一 and Taniguchi, Shin-ichi and 山本, 一博 and Yamamoto, Kazuhiro and Ueta, Etsuko and Nakamura, Risa and Sumi, Keisuke and Matsumoto, Kazuhisa and Shoji, Kyoko and Nomi, Yuri and Mihara, Hitomi},
 journal = {JOURNAL OF DIABETES RESEARCH, JOURNAL OF DIABETES RESEARCH},
 month = {},
 note = {Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods. Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results. CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions. These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes.},
 title = {High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report},
 volume = {2017},
 year = {2017},
 yomi = {オオクラ, ツヨシ and フジオカ, ヨウヘイ and スミ, ケイスケ and マツザワ, カズヒコ and イザワ, ショウイチロウ and オオツカ, ユズル and カトウ, マサヒコ and タニグチ, シンイチ and ヤマモト, カズヒロ and スミ, ケイスケ}
}