{"created":"2023-08-02T03:58:06.573200+00:00","id":7257,"links":{},"metadata":{"_buckets":{"deposit":"ec272a27-5f35-4f90-85bf-7656189f7b74"},"_deposit":{"created_by":10,"id":"7257","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7257"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007257","sets":["1:9","2:12"]},"author_link":["2790","349","26924","2090","1167","3014","1364","3805","4288","26925","26926","26927","26928","26929","26930","26931"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"2017","bibliographic_titles":[{"bibliographic_title":"JOURNAL OF DIABETES RESEARCH"},{"bibliographic_title":"JOURNAL OF DIABETES RESEARCH","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Advanced glycation end products (AGEs) are important in the pathophysiology of type 2 diabetes mellitus (T2DM). They directly cause insulin secretory defects in animal and cell culture models and may promote insulin resistance in nondiabetic subjects. We have developed a highly sensitive liquid chromatography-tandem mass spectrometry method for measuring AGEs in human serum. Here, we use this method to investigate the relationship between AGEs and insulin secretion and resistance in patients with T2DM. Methods. Our study involved 15 participants with T2DM not on medication and 20 nondiabetic healthy participants. We measured the AGE carboxyethyllysine (CEL), carboxymethyllysine (CML), and methyl-glyoxal-hydro-imidazolone (MG-H1). Plasma glucose and insulin were measured in these participants during a meal tolerance test, and the glucose disposal rate was measured during a euglycemic-hyperinsulinemic clamp. Results. CML and CEL levels were significantly higher in T2DM than non-DM participants. CML showed a significant negative correlation with insulin secretion, HOMA-%B, and a significant positive correlation with the insulin sensitivity index in T2DM participants. There was no correlation between any of the AGEs measured and glucose disposal rate. Conclusions. These results suggest that AGE might play a role in the development or prediction of insulin secretory defects in type 2 diabetes.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Hindawi"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2017/5139750","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Okura Tsuyoshi, Ueta Etsuko, Nakamura Risa, et al. High Serum Advanced Glycation End Products Are Associated with Decreased Insulin Secretion in Patients with Type 2 Diabetes: A Brief Report. JOURNAL OF DIABETES RESEARCH. 2017. 2017. doi:10.1155/2017/5139"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.hindawi.com/journals/jdr/2017/5139750/"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.hindawi.com/journals/jdr/2017/5139750/","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2017 Tsuyoshi Okura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23146745","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"23146753"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"School of Health Science, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Regional Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences"},{"subitem_text_language":"en","subitem_text_value":"Department of Food and Nutrition, Toita Women’s College"},{"subitem_text_language":"en","subitem_text_value":"Department of Food and Nutrition, Toita Women’s College"},{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Regional Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Cardiovascular Medicine, Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大倉, 毅"},{"creatorName":"オオクラ, ツヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Okura, 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