{"created":"2023-08-02T03:58:09.686491+00:00","id":7313,"links":{},"metadata":{"_buckets":{"deposit":"fffdd688-57eb-4747-98b7-cc08f136df85"},"_deposit":{"created_by":10,"id":"7313","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7313"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007313","sets":["1:9","2:12"]},"author_link":["4891","1991","4888","1375","27163","1839","4871","27164","27165","27166","27167","27168","27169","27170","27171","27172","27173","27174","27175","27176","27177","27178","27179"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"118","bibliographicPageStart":"100","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Molecular Therapy"},{"bibliographic_title":"Molecular Therapy","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Shiga toxin-producing Escherichia coli (STEC) causes hemorrhagic colitis, hemolytic uremic syndrome, and acute encephalopathies that may lead to sudden death or severe neurologic sequelae. Current treatments, including immunoglobulin G (IgG) immunoadsorption, plasma exchange, steroid pulse therapy, and the monoclonal antibody eculizumab, have limited effects against the severe neurologic sequelae. Multilineage-differentiating stress-enduring (Muse) cells are endogenous reparative non-tumorigenic stem cells that naturally reside in the body and are currently under clinical trials for regenerative medicine. When administered intravenously, Musecells accumulate to the damaged tissue, where they exert anti-inflammatory, anti-apoptotic, anti-fibrotic, and immunomodulatory effects, and replace damaged cells by differentiating into tissue-constituent cells. Here, severely immunocompromised non-obese diabetic/severe combined immunodeficiency (NOD-SCID) mice orally inoculated with 9 × 109 colony-forming units of STEC O111 and treated 48 h later with intravenous injection of 5 × 104 Muse cells exhibited 100% survival and no severe after-effects of infection. Suppression of granulocyte-colony-stimulating factor (G-CSF) by RNAi abolished the beneficial effects of Muse cells, leading to a 40% death and significant body weight loss, suggesting the involvement of G-CSF in the beneficial effects of Muse cells in STEC-infected mice. Thus, intravenous administration of Muse cells could be a candidate therapeutic approach for preventing fatal encephalopathy after STEC infection.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ymthe.2019.09.023","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Ozuru, Ryo. Wakao, Shohei. Tsuji, Takahiro. et al. Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice. Molecular Therapy. 28. 100-118. 2020-01-08."}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.sciencedirect.com/science/article/pii/S1525001619304526"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S1525001619304526","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15250016","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Stem Cell Biology and Histology, Graduate School of Medicine, Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences"},{"subitem_text_language":"en","subitem_text_value":"Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Hasanuddin University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Bacteriology, Toyama Institute of Health"},{"subitem_text_language":"en","subitem_text_value":"Division of Legal Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"},{"subitem_text_language":"en","subitem_text_value":"Department of Forensic Medicine, The Jikei University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Forensic Medicine, The Jikei University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Food Microbiology, Tokyo Metropolitan Institute of Public"},{"subitem_text_language":"en","subitem_text_value":"Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University"},{"subitem_text_language":"en","subitem_text_value":"Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University"},{"subitem_text_language":"en","subitem_text_value":"Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Neuropathology, Department of Brain and Neuroscience, Faculty of Medicine, School of Medicine, Tottori University Faculty of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Clinical Radiology, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Bacteriology, Niigata University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Stem Cell Biology and Histology, Graduate School of Medicine, Tohoku University"},{"subitem_text_language":"en","subitem_text_value":"Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"尾鶴, 亮"},{"creatorName":"オヅル, リョウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ozuru, Ryo","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"松葉, 隆司"},{"creatorName":"マツバ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuba, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"飯野, 守男"},{"creatorName":"イイノ, モリオ","creatorNameLang":"ja-Kana"},{"creatorName":"Iino, Morio","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"加藤, 信介"},{"creatorName":"カトウ, シンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Shinsuke","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"山下, 栄二郎"},{"creatorName":"ヤマシタ, エイジロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"黒沢, 洋一"},{"creatorName":"クロザワ, ヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Kurozawa, Youichi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"藤井, 潤"},{"creatorName":"Fujii, Jun","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Wakao, Shohei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuji, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohara, Naoya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Amuran, Muhammad Y.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isobe, Junko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishida, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Sari","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwadate, Kimiharu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Konishi, Noriko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuda, Kaori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tashiro, Kosuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hida, Misato","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yadoiwa, Arisato","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Eijiro","creatorNameLang":"en"},{"creatorName":"ヤマシタ, エイジロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Sohkichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dezawa, Mari","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"mt28(1)_100.pdf","filesize":[{"value":"6.2 MB"}],"format":"application/pdf","licensefree":"© 2019 The Author(s). 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