{"created":"2023-08-02T03:58:09.903123+00:00","id":7318,"links":{},"metadata":{"_buckets":{"deposit":"b403fbcc-6d57-4013-9467-4744bf62b5d0"},"_deposit":{"created_by":10,"id":"7318","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7318"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007318","sets":["1:10","2:12"]},"author_link":["779","2225","1457","27195","27196","27197","27198"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"NUTRIENTS"},{"bibliographic_title":"NUTRIENTS","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neurological dementias such as Alzheimer’s disease and Lewy body dementia are thought to be caused in part by the formation and deposition of characteristic insoluble fibrils of polypeptides such as amyloid beta (Aβ), Tau, and/or α-synuclein (αSyn). In this context, it is critical to suppress and remove such aggregates in order to prevent and/or delay the progression of dementia in these ailments. In this report, we investigated the effects of spearmint extract (SME) and rosmarinic acid (RA; the major component of SME) on the amyloid fibril formation reactions of αSyn, Aβ, and Tau proteins in vitro. SME or RA was added to soluble samples of each protein and the formation of fibrils was monitored by thioflavin T (ThioT) binding assays and transmission electron microscopy (TEM). We also evaluated whether preformed amyloid fibrils could be dissolved by the addition of RA. Our results reveal for the first time that SME and RA both suppress amyloid fibril formation, and that RA could disassemble preformed fibrils of αSyn, Aβ, and Tau into non-toxic species. Our results suggest that SME and RA may potentially suppress amyloid fibrils implicated in the progression of Alzheimer’s disease and Lewy body dementia in vivo, as well.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/nu12113480","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Ogawa Kenjirou, Ishii Ayumi, Shindo Aimi, et al. Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia. NUTRIENTS. 2020. 12(11). doi:10.3390/nu12113480"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.mdpi.com/2072-6643/12/11/3480"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.mdpi.com/2072-6643/12/11/3480","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)."}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"20726643"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Organization for Promotion of Tenure Track, University of Miyazaki"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"R&D Department,Wakasa Seikatsu Co. Ltd."},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Center for Research on Green Sustainable Chemistry, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本郷, 邦広"},{"creatorName":"ホンゴウ, クニヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Hongo, Kunihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"779","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80335504","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80335504"},{"nameIdentifier":"100000563","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000563_ja.html"}]},{"creatorNames":[{"creatorName":"溝端, 知宏"},{"creatorName":"ミゾバタ, トモヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Mizobata, Tomohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2225","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50263489","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50263489"},{"nameIdentifier":"100000572","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000572_ja.html"}]},{"creatorNames":[{"creatorName":"河田, 康志"},{"creatorName":"カワタ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawata, Yasushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1457","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40177697","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40177697"},{"nameIdentifier":"100000496","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000496_ja.html"}]},{"creatorNames":[{"creatorName":"Ogawa, Kenjirou","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27195","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Ayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27196","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shindo, Aimi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sogon, Tetsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27198","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"nt12(11)_nu12113480.pdf","filesize":[{"value":"771.6 kB"}],"format":"application/pdf","licensefree":"(C) 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nt12(11)_nu12113480.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7318/files/nt12(11)_nu12113480.pdf"},"version_id":"7b39ee42-1eac-45c0-a798-f5fa626b7c95"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"spearmint","subitem_subject_scheme":"Other"},{"subitem_subject":"rosmarinic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"polyphenol","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid fibril","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid beta","subitem_subject_scheme":"Other"},{"subitem_subject":"alpha-synuclein","subitem_subject_scheme":"Other"},{"subitem_subject":"Tau","subitem_subject_scheme":"Other"},{"subitem_subject":"dementia","subitem_subject_scheme":"Other"},{"subitem_subject":"spearmint","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rosmarinic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polyphenol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid fibril","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid beta","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alpha-synuclein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tau","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dementia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","10"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-06-30"},"publish_date":"2022-06-30","publish_status":"0","recid":"7318","relation_version_is_last":true,"title":["Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:45:31.485149+00:00"}