{"created":"2023-08-02T03:58:11.180220+00:00","id":7340,"links":{},"metadata":{"_buckets":{"deposit":"7f053fb2-2b8c-4345-8757-e3dc0b47d47b"},"_deposit":{"created_by":10,"id":"7340","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7340"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007340","sets":["1:9","2:12"]},"author_link":["27308","27309","27310","27311","27312","27313","2308","27314"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"3586","bibliographicPageStart":"3581","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"PNAS : proceedings of the National Academy of Sciences of the United States of America"},{"bibliographic_title":"PNAS : proceedings of the National Academy of Sciences of the United States of America","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Reactive gliosis is the universal reaction to brain injury, but the precise origin and subsequent fate of the glial cells reacting to injury are unknown. Astrocytes react to injury by hypertrophy and up-regulation of the glial-fibrillary acidic protein (GFAP). Whereas mature astrocytes do not normally divide, a subpopulation of the reactive GFAP+ cells does so, prompting the question of whether the proliferating GFAP+ cells arise from endogenous glial progenitors or from mature astrocytes that start to proliferate in response to brain injury. Here we show by genetic fate mapping and cell type-specific viral targeting that quiescent astrocytes start to proliferate after stab wound injury and contribute to the reactive gliosis and proliferating GFAP+ cells. These proliferating astrocytes remain within their lineage in vivo, while a more favorable environment in vitro revealed their multipotency and capacity for self-renewal. Conversely, progenitors present in the adult mouse cerebral cortex labeled by NG2 or the receptor for the platelet-derived growth factor (PDGFRα) did not form neurospheres after (or before) brain injury. Taken together, the first fate-mapping analysis of astrocytes in the adult mouse cerebral cortex shows that some astrocytes acquire stem cell properties after injury and hence may provide a promising cell type to initiate repair after brain injury.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Academy of Sciences"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1073/pnas.0709002105","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Annalisa Buffo, Inmaculada Rite, Pratibha Tripathi, Alexandra Lepier, Dilek Colak, Ana-Paula Horn, Tetsuji Mori, Magdalena Götz. Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proceedings of the National Academ"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.pnas.org/content/105/9/3581"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.pnas.org/content/105/9/3581","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2008 by The National Academy of Sciences of the USA"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11726874","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"10916490","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health"},{"subitem_text_language":"en","subitem_text_value":"Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health / Institute of Physiology, University of Munich"},{"subitem_text_language":"en","subitem_text_value":"Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health"},{"subitem_text_language":"en","subitem_text_value":"Institute of Physiology, University of Munich"},{"subitem_text_language":"en","subitem_text_value":"Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health"},{"subitem_text_language":"en","subitem_text_value":"Department of Biochemistry, Federal University of Rio Grande do Sul"},{"subitem_text_language":"en","subitem_text_value":"Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health"},{"subitem_text_language":"en","subitem_text_value":"Institute for Stem Cell Research, GSF-National Research Institute for Environment and Health"}]},"item_10001_text_34":{"attribute_name":"雑誌内区分","attribute_value_mlt":[{"subitem_text_value":"RESEARCH ARTICLE"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Buffo, Annalisa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Rite, Inmaculada","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tripathi, Pratibha","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lepier, Alexandra","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Colak, Dilek","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horn, Ana-Paula","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Tetsuji","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Götz, Magdalena","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"pnas105(9)_3581.pdf","filesize":[{"value":"4.7 MB"}],"format":"application/pdf","licensefree":"© 2008 by The National Academy of Sciences of the USA","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"pnas105(9)_3581.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7340/files/pnas105(9)_3581.pdf"},"version_id":"fa307cf1-1149-4863-8251-7fa0eeb7da61"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"astrocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"cell fate","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebral cortex","subitem_subject_scheme":"Other"},{"subitem_subject":"stem cells","subitem_subject_scheme":"Other"},{"subitem_subject":"astrocytes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell fate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebral cortex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-08"},"publish_date":"2020-01-08","publish_status":"0","recid":"7340","relation_version_is_last":true,"title":["Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:46:42.650642+00:00"}