{"created":"2023-08-02T03:58:11.442950+00:00","id":7344,"links":{},"metadata":{"_buckets":{"deposit":"b8024209-fb3b-4b45-a811-dd0ea5bec8d8"},"_deposit":{"created_by":10,"id":"7344","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7344"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007344","sets":["1:10","2:12"]},"author_link":["4648","4763","27321","27322","27323","27324","27325"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1151","bibliographicPageStart":"1143","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"POLYMER JOURNAL"},{"bibliographic_title":"POLYMER JOURNAL","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The cyclization of peptides is a valuable strategy for the development of binding motifs to target proteins with improved affinity. Microtubules (MTs) are important targets for therapeutics, and a variety of MT-targeted drugs and peptides have recently been developed. We have previously designed a Tau-derived peptide (TP) that binds to the interior of MTs. In the present study, the development of a cyclic TP (TCP) for enhanced binding to tubulin and the stabilization of MTs is described. The fluorescently labeled cyclic peptide containing three glycine linkers (TCP3-TMR) exhibited a remarkably enhanced binding affinity to tubulin. The cyclic peptide was also demonstrated to stabilize MTs by enhancing polymerization and reducing depolymerization. Moreover, MTs were effectively formed by the treatment of cyclic peptides in the presence of guanosine triphosphate (GTP), while the linear peptide showed no such effect. These findings indicate that TCP is a useful binding motif that can stabilize MTs and is valuable for various therapeutic and material applications.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41428-020-0356-3","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Inaba Hiroshi, Nagata Miyuu, Miyake Kyeongmi Juliano, et al. Cyclic Tau-derived peptides for stabilization of microtubules. POLYMER JOURNAL. 2020. 52(9). 1143-1151. doi:10.1038/s41428-020-0356-3"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1038/s41428-020-0356-3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41428-020-0356-3","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2020 Springer Nature. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improve"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00323896","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_26":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_text_value":"13490540"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Centre for Research on Green Sustainable Chemistry, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Science, Hokkaido University"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Science, Hokkaido University / Graduate School of Chemical Sciences and Engineering, Hokkaido University"},{"subitem_text_language":"en","subitem_text_value":"Faculty of Science, Hokkaido University / Graduate School of Chemical Sciences and Engineering, Hokkaido University"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University / Centre for Research on Green Sustainable Chemistry, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲葉, 央"},{"creatorName":"イナバ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Inaba, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"松浦, 和則"},{"creatorName":"マツウラ, カズノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuura, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nagata, Miyuu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyake, Kyeongmi Juliano","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kabir, Arif Md. Rashedul","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kakugo, Akira","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sada, Kazuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"pj52(9)_1143.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensefree":"(C) 2020 Springer Nature. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improve","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"pj52(9)_1143.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7344/files/pj52(9)_1143.pdf"},"version_id":"3016ed99-fa5b-4ef6-8566-cefe23c97d15"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Cyclic Tau-derived peptides for stabilization of microtubules","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cyclic Tau-derived peptides for stabilization of microtubules","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","10"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-08-03"},"publish_date":"2022-08-03","publish_status":"0","recid":"7344","relation_version_is_last":true,"title":["Cyclic Tau-derived peptides for stabilization of microtubules"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-11-22T01:51:29.544860+00:00"}