{"created":"2023-08-02T03:58:11.779213+00:00","id":7350,"links":{},"metadata":{"_buckets":{"deposit":"4d95fcad-7d6c-49b4-9a44-b67dec821b98"},"_deposit":{"created_by":10,"id":"7350","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7350"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007350","sets":["1:9","2:12"]},"author_link":["4866","3368"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"33","bibliographicPageStart":"20","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Regenerative Therapy"},{"bibliographic_title":"Regenerative Therapy","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have successfully improved outcomes in several tumor types. In addition, currently, immune cell-based therapy is also attracting significant attention. However, the clinical efficacy of these treatments requires further improvement. The mechanisms through which cancer cells escape the immune response must be identified and clarified. Cancer stem cells (CSCs) play a central role in multiple aspects of malignant tumors. CSCs can initiate tumors in partially immunocompromised mice, whereas non-CSCs fail to form tumors, suggesting that tumor initiation is a definitive function of CSCs. However, the fact that non-CSCs also initiate tumors in more highly immunocompromised mice suggests that the immune evasion property may be a more fundamental feature of CSCs rather than a tumor-initiating property. In this review, we summarize studies that have elucidated how CSCs evade tumor immunity and create an immunosuppressive milieu with a focus on CSC-specific characteristics and functions. These profound mechanisms provide important clues for the development of novel tumor immunotherapies.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.reth.2021.02.006","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Tsuchiya, Hiroyuki. Shiota, Goshi. Immune evasion by cancer stem cells. Regenerative Therapy. 17. 20-33. doi:10.1016/j.reth.2021.02.006"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.sciencedirect.com/science/article/pii/S2352320421000134"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S2352320421000134","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"©2021, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)."}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"23523204","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Division of Medical Genetics and Regenerative Medicine, Department of Genomic Medicine and Regenerative Therapy, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Division of Medical Genetics and Regenerative Medicine, Department of Genomic Medicine and Regenerative Therapy, Faculty of Medicine, Tottori University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土谷, 博之"},{"creatorName":"ツチヤ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchiya, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"汐田, 剛史"},{"creatorName":"シオタ, ゴウシ","creatorNameLang":"ja-Kana"},{"creatorName":"Shiota, Goshi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-17"}],"displaytype":"detail","filename":"rt17_20.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensefree":"©2021, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"rt17_20.pdf","url":"https://repository.lib.tottori-u.ac.jp/record/7350/files/rt17_20.pdf"},"version_id":"4cdd58d1-46d3-443a-a61d-5c3a28a2aa27"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cancer stem cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune evasion","subitem_subject_scheme":"Other"},{"subitem_subject":"T cells","subitem_subject_scheme":"Other"},{"subitem_subject":"NK cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune checkpoints","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune evasion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NK cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immune checkpoints","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"Immune evasion by cancer stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immune evasion by cancer stem cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"10","path":["12","9"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-08"},"publish_date":"2021-09-08","publish_status":"0","recid":"7350","relation_version_is_last":true,"title":["Immune evasion by cancer stem cells"],"weko_creator_id":"10","weko_shared_id":-1},"updated":"2023-09-29T00:47:20.029122+00:00"}