{"created":"2023-08-02T03:58:12.773162+00:00","id":7370,"links":{},"metadata":{"_buckets":{"deposit":"4c7d6ac2-23f3-4b0d-90c9-c3da83cedd4c"},"_deposit":{"created_by":10,"id":"7370","owners":[10],"pid":{"revision_id":0,"type":"depid","value":"7370"},"status":"published"},"_oai":{"id":"oai:repository.lib.tottori-u.ac.jp:00007370","sets":["1:9","2:12"]},"author_link":["27414","1879","1367","27415","27416","27417","1457","3805","2609","765","27418","27419","27420","27421","27422","27423","27424","27425","27426","27427","27428","27429","27430","27431"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-07-11","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"SCIENTIFIC REPORTS"},{"bibliographic_title":"SCIENTIFIC REPORTS","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibit its activity. Molecular dynamic calculation indicated that these LAs were bound to the β5 subunit of the 20S proteasome, and not to the other active subunits, β1 and β2. Consistently, pilsicainide inhibited only chymotrypsin-like activity, whereas it did not inhibit the caspase-like and trypsin-like activities. In addition, we confirmed that the aromatic ring of these LAs was critical for inhibiting the proteasome. These LAs stabilized p53 and suppressed proliferation of p53-positive but not of p53-negative cancer cells.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-017-04652-2","subitem_relation_type_select":"DOI"}}]},"item_10001_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Bahrudin Udin, Unno Masaki, Nishio Kazuya, et al. Inhibitory effects of local anesthetics on the proteasome and their biological actions. SCIENTIFIC REPORTS. 2017. 7. doi:10.1038/s41598-017-04652-2"}]}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://www.nature.com/articles/s41598-017-04652-2"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41598-017-04652-2","subitem_relation_type_select":"URI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and th"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_33":{"attribute_name":"著者所属（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University / Present address: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Diponegoro University"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Science and Engineering, Ibaraki University / Frontier Research Center for Applied Atomic Sciences, Ibaraki University"},{"subitem_text_language":"en","subitem_text_value":"Research Reactor Institute, Kyoto University / Present address: Graduate School of Life Science, University of Hyogo"},{"subitem_text_language":"en","subitem_text_value":"Research Reactor Institute, Kyoto University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Surgery, National Hospital Organization Kure Medical Center"},{"subitem_text_language":"en","subitem_text_value":"Cancer Center, Tottori University Hospital"},{"subitem_text_language":"en","subitem_text_value":"School of Science and Technology, Kwansei Gakuin University / RIKEN SPring-8 Center, RIKEN Harima Institute"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Science and Engineering, Ibaraki University"},{"subitem_text_language":"en","subitem_text_value":"Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science"},{"subitem_text_language":"en","subitem_text_value":"Graduate School of Science and Engineering, Ibaraki University / Frontier Research Center for Applied Atomic Sciences, Ibaraki University"},{"subitem_text_language":"en","subitem_text_value":"Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science"},{"subitem_text_language":"en","subitem_text_value":"School of Science and Technology, Kwansei Gakuin University / RIKEN SPring-8 Center, RIKEN Harima Institute"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Department of Biological Regulation, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University"},{"subitem_text_language":"en","subitem_text_value":"Research Reactor Institute, Kyoto University"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bahrudin, Udin"},{"creatorName":"バフルディン, ウディン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"27414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"李, 佩俐"},{"creatorName":"リ, ペイリ","creatorNameLang":"ja-Kana"},{"creatorName":"Li, 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ハルアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ninomiya, Haruaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2609","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80212124","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80212124"},{"nameIdentifier":"100000212","nameIdentifierScheme":"研究者総覧鳥取大学","nameIdentifierURI":"http://researchers.adm.tottori-u.ac.jp/html/100000212_ja.html"}]},{"creatorNames":[{"creatorName":"久留, 一郎"},{"creatorName":"ヒサトメ, イチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Hisatome, 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